Macrophage-Based Therapies for Atherosclerosis Management

Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target...

Full description

Saved in:
Bibliographic Details
Published inJournal of Immunology Research Vol. 2020; no. 2020; pp. 1 - 11
Main Authors Wu, Wei, Sun, Da, Xu, Ke, Huang, Yijiang, Lin, Sue, Jin, Libo, Ji, Hao, Peng, Renyi, Yang, Qinsi
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Animals
Apoptosis
Arteriosclerosis
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - immunology
Autophagy
Autophagy - drug effects
Autophagy - immunology
Blood circulation disorders
Cardiovascular Agents - pharmacology
Cardiovascular Agents - therapeutic use
Cardiovascular disease
Cell Membrane - drug effects
Cell Membrane - immunology
Cerebrovascular diseases
Cholesterol
Coronary heart disease
Disease Models, Animal
Drug Carriers - pharmacology
Drug delivery systems
Drugs
Gene expression
Humans
Immunology
Inflammasomes - drug effects
Inflammasomes - immunology
Inflammation
Ischemia
Kinases
Lipids
Lipoproteins
Macrophage Activation - drug effects
Macrophage Activation - immunology
Macrophages
Macrophages - cytology
Macrophages - drug effects
Macrophages - immunology
Management
Oxidative stress
Pathogenesis
Phagocytosis
Proteins
Review
Vascular diseases
Vehicles
China
Online AccessGet full text

Cover

Abstract Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient and safe management of AS. In this review, we focused on the systematical summary of the macrophage-based therapies in AS management, including macrophage autophagy, polarization, targeted delivery, microenvironment-triggered drug release, and macrophage- or macrophage membrane-based drug carrier. In conclusion, macrophage-based therapies have great promise to effectively manage AS in future research and clinic translation.
AbstractList Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient and safe management of AS. In this review, we focused on the systematical summary of the macrophage- based therapies in AS management, including macrophage autophagy, polarization, targeted delivery, microenvironment- triggered drug release, and macrophage- or macrophage membrane-based drug carrier. In conclusion, macrophage-based therapies have great promise to effectively manage AS in future research and clinic translation.
Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient and safe management of AS. In this review, we focused on the systematical summary of the macrophage-based therapies in AS management, including macrophage autophagy, polarization, targeted delivery, microenvironment-triggered drug release, and macrophage- or macrophage membrane-based drug carrier. In conclusion, macrophage-based therapies have great promise to effectively manage AS in future research and clinic translation.Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient and safe management of AS. In this review, we focused on the systematical summary of the macrophage-based therapies in AS management, including macrophage autophagy, polarization, targeted delivery, microenvironment-triggered drug release, and macrophage- or macrophage membrane-based drug carrier. In conclusion, macrophage-based therapies have great promise to effectively manage AS in future research and clinic translation.
Audience Academic
Author Huang, Yijiang
Jin, Libo
Sun, Da
Xu, Ke
Lin, Sue
Ji, Hao
Wu, Wei
Peng, Renyi
Yang, Qinsi
AuthorAffiliation 3 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
1 Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China
5 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China
2 Biomedical Collaborative Innovation Center of Zhejiang Province & Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou, Zhejiang 325035, China
4 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China
AuthorAffiliation_xml – name: 3 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
– name: 1 Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China
– name: 5 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China
– name: 4 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China
– name: 2 Biomedical Collaborative Innovation Center of Zhejiang Province & Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou, Zhejiang 325035, China
Author_xml – sequence: 1
  fullname: Wu, Wei
– sequence: 2
  fullname: Sun, Da
– sequence: 3
  fullname: Xu, Ke
– sequence: 4
  fullname: Huang, Yijiang
– sequence: 5
  fullname: Lin, Sue
– sequence: 6
  fullname: Jin, Libo
– sequence: 7
  fullname: Ji, Hao
– sequence: 8
  fullname: Peng, Renyi
– sequence: 9
  fullname: Yang, Qinsi
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32411803$$D View this record in MEDLINE/PubMed
BookMark eNqFkt1r1EAUxYNUbK1981kWBBE07Xxn8iKsxY9Ciy_1ebiZ3NlMSTLrTFbxv3fibmu3KBKYZCa_e3LuzXlaHIxhxKJ4TskppVKeMcLImaacVlI8Ko4Yp6KsqFQHu2etFT0sTlLyDZGk4lxp9aQ45ExQqgk_KuorsDGsO1hh-R4StovrDiOsPaaFC3GxnPI2JNvPq0-LKxgzOuA4PSseO-gTnuzux8XXjx-uzz-Xl18-XZwvL0uruJzKFp22GnnLEKB1TBAkHEBaRiuEVgJxTIFyhJDa1pxQpRpXOV2DItpSxo-Li61uG-DGrKMfIP40Abz5fRDiykCcfHZoNAGshWpl0zBRNwJQaySW1LypqBAya73baq03zYCtzW1E6PdE99-MvjOr8N1UjAhKZjOvdwIxfNtgmszgk8W-hxHDJpncnsiDVvWMvnyA3oRNHPOoDOOSyZqy_EPuqBXkBvzoQv6unUXNUjFKNK_l7Pv0L1S-Why8zZFwPp_vFby6V9Ah9FOXQr-ZfBjTPvji_kTuRnGbkAywLZBjklJEZ6yfYNbJFnxvKDFzEs2cRLNLYi56-6DoVvcf-Jst3vmxhR_-f_TOMmYGHfyhqa4k4_wXom_wxw
CitedBy_id crossref_primary_10_1002_btm2_10717
crossref_primary_10_1016_j_carbpol_2024_123174
crossref_primary_10_1172_jci_insight_152271
crossref_primary_10_1155_2022_7172583
crossref_primary_10_3390_pharmaceutics13030348
crossref_primary_10_1093_rb_rbac103
crossref_primary_10_1016_j_cpcardiol_2022_101311
crossref_primary_10_7717_peerj_16122
crossref_primary_10_1007_s13346_021_01110_5
crossref_primary_10_1096_fj_202403281R
crossref_primary_10_3389_fimmu_2022_948314
crossref_primary_10_1016_j_nano_2021_102385
crossref_primary_10_3390_pharmaceutics14050923
crossref_primary_10_1007_s10557_023_07513_5
crossref_primary_10_1186_s12951_023_01904_4
crossref_primary_10_1155_2020_8848930
crossref_primary_10_2147_IJN_S290537
crossref_primary_10_2967_jnumed_123_266910
crossref_primary_10_3892_etm_2021_10926
crossref_primary_10_1002_2211_5463_13365
crossref_primary_10_3390_jcdd10100416
crossref_primary_10_3389_fcell_2021_687169
crossref_primary_10_2147_IJN_S298159
crossref_primary_10_1007_s00109_021_02117_8
crossref_primary_10_1002_btm2_10441
crossref_primary_10_3390_pharmaceutics13091452
crossref_primary_10_1016_j_jconrel_2023_12_020
crossref_primary_10_1080_14728222_2023_2288272
crossref_primary_10_1088_1361_6528_ac007d
Cites_doi 10.1039/c3nr05444f
10.1016/j.jconrel.2004.10.014
10.1073/pnas.1424594112
10.1016/j.cmet.2013.04.001
10.3892/ijmm.2013.1609
10.1016/j.cmet.2012.02.011
10.1021/bc100354m
10.1038/nmat4644
10.3892/ijmm.2019.4286
10.1161/01.ATV.0000203503.82693.c1
10.1161/CIRCRESAHA.115.306256
10.1016/j.tem.2014.03.010
10.1208/s12249-011-9668-0
10.1007/s00281-019-00748-1
10.1016/j.ijbiomac.2017.01.037
10.1016/j.bbalip.2009.06.004
10.1155/2019/8563845
10.1038/nrd3802
10.1073/pnas.0809784106
10.1016/j.jjcc.2017.03.005
10.3109/1061186X.2015.1052074
10.1016/j.cyto.2017.06.003
10.1021/acs.bioconjchem.6b00569
10.1016/j.biomaterials.2019.119550
10.1016/j.bbrc.2012.07.086
10.1007/s00018-019-03371-3
10.1016/j.immuni.2014.01.004
10.1021/mp300434e
10.1016/j.jff.2015.08.018
10.1073/pnas.0730843100
10.1038/ni.2215
10.1016/j.biopha.2019.109375
10.1016/j.bbrc.2009.02.161
10.1021/nn503779d
10.1016/j.jconrel.2015.07.019
10.3892/mmr.2017.7032
10.1038/nnano.2007.387
10.1021/am5036225
10.1038/aps.2015.87
10.1016/j.yjmcc.2015.11.012
10.1111/1755-5922.12262
10.1155/2016/7589813
10.7150/thno.7101
10.1002/adhm.201200138
10.1016/j.carrev.2014.05.007
10.1016/j.jep.2017.12.031
10.1517/17425247.2011.559457
10.1016/j.numecd.2011.12.010
10.1080/2162402X.2019.1659096
10.1016/j.jacc.2017.11.055
10.1016/j.cellimm.2018.01.020
10.1038/nrd3499
10.1155/2019/7434376
10.1161/CIRCRESAHA.119.315175
10.1253/circj.68.396
10.1016/j.cell.2011.04.005
10.5551/jat.35634
10.1007/s00395-015-0491-8
10.1155/2011/727241
10.1021/acs.bioconjchem.6b00600
10.2967/jnumed.109.071324
10.1186/s12950-019-0212-4
10.1016/j.bbrc.2005.11.091
10.1039/c3nr00015j
10.1161/CIRCRESAHA.107.168070
10.1161/ATVBAHA.115.306670
10.1016/j.molimm.2017.02.013
10.1016/j.tcm.2019.01.004
10.1016/j.ijpharm.2011.07.039
10.1073/pnas.1106634108
10.1126/scisignal.aad5614
10.1016/j.jss.2019.06.060
10.1590/1414-431x20165195
10.1161/CIRCRESAHA.116.305811
10.1161/circresaha.113.301086
10.1007/s10787-019-00658-6
10.1021/acs.biomac.7b00728
10.1038/nri3520
10.1074/jbc.C000761200
10.1161/ATVBAHA.116.308916
10.1038/nri2675
10.1021/acsnano.6b03148
10.1172/JCI128644
10.1159/000494792
10.1016/j.cyto.2017.10.012
10.1007/s00441-004-1071-7
10.1016/j.atherosclerosis.2014.01.040
10.1042/BSR20180650
10.1007/s10753-018-0793-8
10.3389/fimmu.2019.02217
10.18632/aging.102570
10.3892/mmr.2019.10581
10.1007/s11883-012-0240-5
10.1161/ATVBAHA.110.205617
10.7150/thno.22078
10.1161/ATVBAHA.119.313200
10.1186/s41232-017-0050-9
10.1111/bcp.12820
10.3892/mmr.2014.2790
10.1016/j.cell.2012.12.018
10.1016/j.ijcard.2013.12.168
10.1155/2015/851252
10.1016/j.carpath.2017.08.001
10.1093/cvr/cvy007
ContentType Journal Article
Copyright Copyright © 2020 Renyi Peng et al.
COPYRIGHT 2020 John Wiley & Sons, Inc.
Copyright © 2020 Renyi Peng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0
Copyright © 2020 Renyi Peng et al. 2020
Copyright_xml – notice: Copyright © 2020 Renyi Peng et al.
– notice: COPYRIGHT 2020 John Wiley & Sons, Inc.
– notice: Copyright © 2020 Renyi Peng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0
– notice: Copyright © 2020 Renyi Peng et al. 2020
DBID ADJCN
AHFXO
RHU
RHW
RHX
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T5
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
CWDGH
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1155/2020/8131754
DatabaseName الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals
معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete
Hindawi Publishing Complete
Hindawi Publishing Subscription Journals
Hindawi Publishing Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
Middle East & Africa Database
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Middle East & Africa Database
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList


MEDLINE


CrossRef
Publicly Available Content Database

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: RHX
  name: Hindawi Publishing Open Access
  url: http://www.hindawi.com/journals/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2314-7156
Editor Sharawy, Nivin
Editor_xml – sequence: 1
  givenname: Nivin
  surname: Sharawy
  fullname: Sharawy, Nivin
EndPage 11
ExternalDocumentID oai_doaj_org_article_80ae946d5bb249b4ae88e0c093b71445
PMC7204102
A621083955
32411803
10_1155_2020_8131754
1187523
Genre Journal Article
Review
GeographicLocations China
GeographicLocations_xml – name: China
GrantInformation_xml – fundername: Natural Science Foundation of Zhejiang Province
  grantid: LQ20C200015; LQ20C020003; LQ19E010004
– fundername: Chongqing Research Program of Basic Research and Frontier Technology
  grantid: cstc2017jcyjAX0186
– fundername: Wenzhou Municipal Science and Technology Bureau
  grantid: N20170005
– fundername: National Natural Science Foundation of China
  grantid: 51603023; 31971301; 51901160
– fundername: Fundamental Research Funds for the Central Universities
  grantid: 2018CDHB1B08
GroupedDBID 24P
3V.
53G
5VS
7X7
7XC
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAJEY
AAKDD
ABDBF
ABUWG
ACPRK
ADBBV
ADJCN
ADRAZ
AENEX
AFKRA
AFPKN
AFRAH
AHFXO
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
B0M
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CWDGH
DIK
EAD
EAP
EBD
EBS
EJD
EMB
EMK
EMOBN
EPL
ESX
FYUFA
GROUPED_DOAJ
H13
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
ITC
KQ8
LK8
M1P
M48
M7P
OK1
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RHX
RPM
SV3
TUS
UKHRP
~8M
RHU
RHW
0R~
AAYXX
ACCMX
ACUHS
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
M~E
7T5
7XB
8FK
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
AZQEC
DWQXO
GNUQQ
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c635t-def8c8e3d2eaadf240e03aa5c217ead5a0f26a6f0009c930166bf7f89a608c123
IEDL.DBID M48
ISSN 2314-8861
2314-7156
IngestDate Wed Aug 27 01:32:00 EDT 2025
Thu Aug 21 14:02:05 EDT 2025
Wed Jul 30 11:08:02 EDT 2025
Fri Jul 25 12:18:00 EDT 2025
Wed Oct 16 18:06:02 EDT 2024
Tue Oct 15 04:48:40 EDT 2024
Tue Oct 15 02:43:36 EDT 2024
Thu Apr 03 06:59:48 EDT 2025
Tue Jul 01 03:06:34 EDT 2025
Thu Apr 24 23:03:23 EDT 2025
Sun Jun 02 18:55:04 EDT 2024
Tue Nov 26 17:09:53 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2020
Language English
License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
http://creativecommons.org/licenses/by/4.0
Copyright © 2020 Renyi Peng et al.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c635t-def8c8e3d2eaadf240e03aa5c217ead5a0f26a6f0009c930166bf7f89a608c123
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
Guest Editor: Nivin Sharawy
ORCID 0000-0003-3900-5135
0000-0001-7747-9951
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1155/2020/8131754
PMID 32411803
PQID 2352591207
PQPubID 237305
PageCount 11
ParticipantIDs doaj_primary_oai_doaj_org_article_80ae946d5bb249b4ae88e0c093b71445
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7204102
proquest_miscellaneous_2404050692
proquest_journals_2352591207
gale_infotracmisc_A621083955
gale_infotracacademiconefile_A621083955
gale_healthsolutions_A621083955
pubmed_primary_32411803
crossref_citationtrail_10_1155_2020_8131754
crossref_primary_10_1155_2020_8131754
hindawi_primary_10_1155_2020_8131754
emarefa_primary_1187523
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-00-00
PublicationDateYYYYMMDD 2020-01-01
PublicationDate_xml – year: 2020
  text: 2020-00-00
PublicationDecade 2020
PublicationPlace Cairo, Egypt
PublicationPlace_xml – name: Cairo, Egypt
– name: Egypt
– name: New York
PublicationTitle Journal of Immunology Research
PublicationTitleAlternate J Immunol Res
PublicationYear 2020
Publisher Hindawi Publishing Corporation
Hindawi
John Wiley & Sons, Inc
Wiley
Publisher_xml – name: Hindawi Publishing Corporation
– name: Hindawi
– name: John Wiley & Sons, Inc
– name: Wiley
References 88
89
(74) 2004; 68
90
91
92
93
94
95
96
97
10
98
11
99
12
14
15
16
17
18
19
1
2
3
4
5
6
7
8
9
20
21
22
23
24
25
26
27
28
29
(13) 2019; 20
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
(106) 2018; 53
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
75
76
77
78
79
100
101
102
103
104
105
80
81
82
83
84
85
86
87
References_xml – ident: 91
  doi: 10.1039/c3nr05444f
– ident: 77
  doi: 10.1016/j.jconrel.2004.10.014
– ident: 79
  doi: 10.1073/pnas.1424594112
– ident: 67
  doi: 10.1016/j.cmet.2013.04.001
– ident: 45
  doi: 10.3892/ijmm.2013.1609
– ident: 35
  doi: 10.1016/j.cmet.2012.02.011
– ident: 1
  doi: 10.1021/bc100354m
– ident: 101
  doi: 10.1038/nmat4644
– ident: 8
  doi: 10.3892/ijmm.2019.4286
– ident: 31
  doi: 10.1161/01.ATV.0000203503.82693.c1
– volume: 20
  issue: 23, article 6093
  year: 2019
  ident: 13
  publication-title: International Journal of Molecular Sciences
– ident: 18
  doi: 10.1161/CIRCRESAHA.115.306256
– ident: 2
  doi: 10.1016/j.tem.2014.03.010
– ident: 85
  doi: 10.1208/s12249-011-9668-0
– ident: 39
  doi: 10.1007/s00281-019-00748-1
– ident: 78
  doi: 10.1016/j.ijbiomac.2017.01.037
– ident: 9
  doi: 10.1016/j.bbalip.2009.06.004
– ident: 87
  doi: 10.1155/2019/8563845
– ident: 27
  doi: 10.1038/nrd3802
– ident: 57
  doi: 10.1073/pnas.0809784106
– ident: 84
  doi: 10.1016/j.jjcc.2017.03.005
– ident: 93
  doi: 10.3109/1061186X.2015.1052074
– ident: 22
  doi: 10.1016/j.cyto.2017.06.003
– ident: 97
  doi: 10.1021/acs.bioconjchem.6b00569
– ident: 26
  doi: 10.1016/j.biomaterials.2019.119550
– ident: 60
  doi: 10.1016/j.bbrc.2012.07.086
– ident: 25
  doi: 10.1007/s00018-019-03371-3
– ident: 58
  doi: 10.1016/j.immuni.2014.01.004
– ident: 75
  doi: 10.1021/mp300434e
– ident: 73
  doi: 10.1016/j.jff.2015.08.018
– ident: 66
  doi: 10.1073/pnas.0730843100
– ident: 40
  doi: 10.1038/ni.2215
– ident: 51
  doi: 10.1016/j.biopha.2019.109375
– ident: 14
  doi: 10.1016/j.bbrc.2009.02.161
– ident: 96
  doi: 10.1021/nn503779d
– ident: 98
  doi: 10.1016/j.jconrel.2015.07.019
– ident: 33
  doi: 10.3892/mmr.2017.7032
– ident: 90
  doi: 10.1038/nnano.2007.387
– ident: 94
  doi: 10.1021/am5036225
– ident: 28
  doi: 10.1038/aps.2015.87
– ident: 47
  doi: 10.1016/j.yjmcc.2015.11.012
– ident: 3
  doi: 10.1111/1755-5922.12262
– ident: 44
  doi: 10.1155/2016/7589813
– ident: 88
  doi: 10.7150/thno.7101
– ident: 89
  doi: 10.1002/adhm.201200138
– ident: 43
  doi: 10.1016/j.carrev.2014.05.007
– ident: 32
  doi: 10.1016/j.jep.2017.12.031
– ident: 102
  doi: 10.1517/17425247.2011.559457
– ident: 59
  doi: 10.1016/j.numecd.2011.12.010
– ident: 54
  doi: 10.1080/2162402X.2019.1659096
– ident: 70
  doi: 10.1016/j.jacc.2017.11.055
– ident: 5
  doi: 10.1016/j.cellimm.2018.01.020
– ident: 100
  doi: 10.1038/nrd3499
– ident: 104
  doi: 10.1155/2019/7434376
– ident: 64
  doi: 10.1161/CIRCRESAHA.119.315175
– volume: 68
  start-page: 396
  year: 2004
  ident: 74
  publication-title: Circulation Journal
  doi: 10.1253/circj.68.396
– ident: 4
  doi: 10.1016/j.cell.2011.04.005
– ident: 37
  doi: 10.5551/jat.35634
– ident: 61
  doi: 10.1007/s00395-015-0491-8
– ident: 21
  doi: 10.1155/2011/727241
– ident: 86
  doi: 10.1021/acs.bioconjchem.6b00600
– ident: 81
  doi: 10.2967/jnumed.109.071324
– ident: 29
  doi: 10.1186/s12950-019-0212-4
– ident: 11
  doi: 10.1016/j.bbrc.2005.11.091
– ident: 99
  doi: 10.1039/c3nr00015j
– ident: 24
  doi: 10.1161/CIRCRESAHA.107.168070
– ident: 16
  doi: 10.1161/ATVBAHA.115.306670
– ident: 36
  doi: 10.1016/j.molimm.2017.02.013
– ident: 7
  doi: 10.1016/j.tcm.2019.01.004
– ident: 83
  doi: 10.1016/j.ijpharm.2011.07.039
– ident: 95
  doi: 10.1073/pnas.1106634108
– ident: 30
  doi: 10.1126/scisignal.aad5614
– ident: 20
  doi: 10.1016/j.jss.2019.06.060
– ident: 55
  doi: 10.1590/1414-431x20165195
– ident: 12
  doi: 10.1161/CIRCRESAHA.116.305811
– ident: 19
  doi: 10.1161/circresaha.113.301086
– ident: 68
  doi: 10.1007/s10787-019-00658-6
– volume: 53
  start-page: 297
  issue: 2
  year: 2018
  ident: 106
  publication-title: Acta Pharmaceutica Sinica
– ident: 82
  doi: 10.1021/acs.biomac.7b00728
– ident: 15
  doi: 10.1038/nri3520
– ident: 76
  doi: 10.1074/jbc.C000761200
– ident: 46
  doi: 10.1161/ATVBAHA.116.308916
– ident: 69
  doi: 10.1038/nri2675
– ident: 92
  doi: 10.1021/acsnano.6b03148
– ident: 6
  doi: 10.1172/JCI128644
– ident: 50
  doi: 10.1159/000494792
– ident: 23
  doi: 10.1016/j.cyto.2017.10.012
– ident: 80
  doi: 10.1007/s00441-004-1071-7
– ident: 42
  doi: 10.1016/j.atherosclerosis.2014.01.040
– ident: 48
  doi: 10.1042/BSR20180650
– ident: 62
  doi: 10.1007/s10753-018-0793-8
– ident: 53
  doi: 10.3389/fimmu.2019.02217
– ident: 56
  doi: 10.18632/aging.102570
– ident: 71
  doi: 10.3892/mmr.2019.10581
– ident: 52
  doi: 10.1007/s11883-012-0240-5
– ident: 17
  doi: 10.1161/ATVBAHA.110.205617
– ident: 103
  doi: 10.7150/thno.22078
– ident: 10
  doi: 10.1161/ATVBAHA.119.313200
– ident: 38
  doi: 10.1186/s41232-017-0050-9
– ident: 34
  doi: 10.1111/bcp.12820
– ident: 49
  doi: 10.3892/mmr.2014.2790
– ident: 65
  doi: 10.1016/j.cell.2012.12.018
– ident: 72
  doi: 10.1016/j.ijcard.2013.12.168
– ident: 105
  doi: 10.1155/2015/851252
– ident: 41
  doi: 10.1016/j.carpath.2017.08.001
– ident: 63
  doi: 10.1093/cvr/cvy007
SSID ssib050733686
ssj0001213421
Score 2.398121
SecondaryResourceType review_article
Snippet Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD)....
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
hindawi
emarefa
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1
SubjectTerms Animals
Apoptosis
Arteriosclerosis
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - immunology
Autophagy
Autophagy - drug effects
Autophagy - immunology
Blood circulation disorders
Cardiovascular Agents - pharmacology
Cardiovascular Agents - therapeutic use
Cardiovascular disease
Cell Membrane - drug effects
Cell Membrane - immunology
Cerebrovascular diseases
Cholesterol
Coronary heart disease
Disease Models, Animal
Drug Carriers - pharmacology
Drug delivery systems
Drugs
Gene expression
Humans
Immunology
Inflammasomes - drug effects
Inflammasomes - immunology
Inflammation
Ischemia
Kinases
Lipids
Lipoproteins
Macrophage Activation - drug effects
Macrophage Activation - immunology
Macrophages
Macrophages - cytology
Macrophages - drug effects
Macrophages - immunology
Management
Oxidative stress
Pathogenesis
Phagocytosis
Proteins
Review
Vascular diseases
Vehicles
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlEOil9F0329SFlB6KiR-SLB83oSEU2lMCuQlZltmF4g3dDSH_Pt9IWmddWnLpZcGrMfKMZjTzidEMY0eqtLWTPc-EalzGK2syZWB4ppa8cc7BrfgE2Z_y_JJ_vxJXO62-KCcslAcOgjtWuXENl51oWyCFlhunlMstgHhbAwz46qXweTtgCpokqBWhjIXRwmlLUXF_CQvxDM-UksU2C14IOgDIj1VBrpRP_JMv4-_v6ho8m3Hb3l8QYL5d_i0s_TO7csddnT1nz2Kcmc4Dfy_YEze8ZPuh8-TdK9b8MNS7a4HdJDuBI-vSC38RC7g5RRibzikuXK3xKn6X6_QhS-Y1uzz7dnF6nsUuCplFMLHJOtcrq1zVlc6YrocHd3lljLAAI1AjYfK-lEb2FG3ZBvYuZdvXvWqMzJWFY3vD9obV4N6xlFtRIYARQnKgEFhubwTgdSfqtivKvErY163stI0lxqnTxS_toYYQmiSto6QT9nmkvg6lNf5Bd0LLMNJQQWz_B9RERzXRj6lJwt7GRXyYqwBWK_HRH2lRdbh3Ohq8nkugYUXcJuyLpyCTBzvWxJsLEAoVz5pQziaUMFU7GT6KivMIw7OtVum4o6x1SXVrG0i5TtincZgmoCy5wa1uQMOxJYtcNiXYDUo4ToTAmar9gd16op4TsU5HhuXC1xunPkaIQ9__j3U4YE-J1XCINWN7m9837gPCuk176C34HiWAPzg
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Hindawi Publishing Open Access
  dbid: RHX
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELbYpEm8IBi_AgWCNMQDisgP27EfO7SpQoKnTeqb5TiOWgmliHaa9t_zneNmZIDgpVLqax2f73zfl9h3jJ2o0tVedjwTSvuMV85mysLxbC259t4jrIQNsl_l4pJ_XoplTJK0_f0VPqId0fP8oyoo0PEDdgADI1K-WO7NRlDdQRmzoA2PVoqKhxNXAC88U0oW-y3vd_5uEoxCzv5wMNfi2o5r9NGK2PH1-k8Y9O5Wyl9i0_lD9iCCynQ-WMEjds_3x-xoKDN585jpL5YKda2wdGSniFptehFOXYEkp8Cs6ZxA4GaLn-JzvU1vt8Q8YZfnZxefFlksmZA5IIdd1vpOOeWrtvTWth3Ctc8ra4UD84DNCJt3pbSyI2jlNJxbyqarO6WtzJVDFHvKDvtN75-zlDtRAa0IITkoB9y0swJcuhV10xZlXiXsw153xsV84lTW4psJvEIIQ5o2UdMJezdKfx_yaPxF7pSmYZSh7NfhC1iEic5kVG695rIVTQP22HDrlfK5y3XV1CCIImHP4iTe9lWAmJW46Tc0qWY4ZDp6t5lLUF9Fo03Y-yBB_o3hOBuPKUAplClrIjmbSMIv3aT5JBrOPwY821uVicvH1pSUpFZDy3XC3o7N1AFtiev95goyHOuvyKUuMdzBCMeOgJIptR-GW0_Mc6LWaUu_XoXk4lS0CKDzxf_d_Ut2ny6HZ1Izdrj7ceVfAaXtmtfBR38CeJIsrw
  priority: 102
  providerName: Hindawi Publishing
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1La9wwEBZtSqCX0HfdblMXUnooJn5Isnwqm5IQCu0pgb0JWZa7C8VOshtK_32_kbXeuvRxWdjVLPJI8_hGHs0wdqRyWzrZ8kSoyiW8sCZRBopnSskr5xzcik-Q_SLPL_mnhViEA7d1SKvc2kRvqJve0hn5cU51O6ssT8sPV9cJdY2it6uhhcZddo9Kl5FUl4vRnQpqSChDebThzCUruL-KBVTDE6Vkts2FF4KOAdJjlZFD5RMv5Yv5-xu7Bt_NaLz3lxQ2f1_9CZz-nmP5i9M6e8AOAtqM54N4PGR3XPeI7Q_9J388ZtVnQx28lrApyQncWRNf-OtYiJ5jgNl4TuiwX-Ov-Fyt412uzBN2eXZ68fE8Cb0UEgtIsUka1yqrXNHkzpimhR93aWGMsAhJIEzCpG0ujWwJc9kKWi9l3ZatqoxMlYV7e8r2ur5zz1nMrSgAY4SQHLEI9Lc1AkF2I8q6wf4UEXu_XTttQ6Fx6nfxTfuAQwhNK63DSkfs7Uh9NRTY-AvdCW3DSENlsf0P_c1XHbRMq9S4istG1DXCypobp5RLbVoVdYnIUUTsWdjE3VwZIrYcD_2aNlUPt09HtddziZhYEbcRe-cpSPHBjjXh_gIWhUpoTShnE0oorJ0MHwXB-Q_Ds61U6WBX1nqnBRF7Mw7TBJQr17n-FjQchlmkssrB7iCE40SAz1TzD-yWE_GcLOt0pFstfdVx6mYENPri34_1kt0nJoZDqhnb29zculeAbZv60OvmT-I7NvQ
  priority: 102
  providerName: ProQuest
Title Macrophage-Based Therapies for Atherosclerosis Management
URI https://search.emarefa.net/detail/BIM-1187523
https://dx.doi.org/10.1155/2020/8131754
https://www.ncbi.nlm.nih.gov/pubmed/32411803
https://www.proquest.com/docview/2352591207
https://www.proquest.com/docview/2404050692
https://pubmed.ncbi.nlm.nih.gov/PMC7204102
https://doaj.org/article/80ae946d5bb249b4ae88e0c093b71445
Volume 2020
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_tQ0N7QXwTKCVIQzygQJrYjvOAUIs6VaBNMK1S3yzHcWilKYW2E-yFv50756NkGkLixVLrS12f73y_X2TfARzJyCRWFCzgMrUBi40OpEbH04lgqbUWw4o7IHsqJlP2ccZnO9BUG60VuL6R2lE9qenq4s3P71fv0eHfOYfnnPh7-FYOKBKyXdjHmJRQLYOTLdDnVJpQ1InSqrcvg5i5S1mIb1ggpRg0p-Kv_eAh3ELMQYnS4k7ochn-3TVejZ91u6MfzIlL_1jchFivH7z8I5Id34HbNQT1h5XN3IUdW96Dg6oo5dV9SE80lfWa40YTjDDG5f65u6OFlNpHhOsPCTIu1_gotou1vz1A8wCmx-PzD5OgLrAQGMQZmyC3hTTSxnlktc4LDO42jLXmBnkKWhjXYREJLQoCYibFrUCIrEgKmWoRSoMx7yHslcvSPgafGR4jtuFcMCQo6NSF5si8c55k-SAKYw9eN7pTps4-TkUwLpRjIZwrUrqqle7By1b6W5V14y9yI1qGVoZyZbsvlquvqnY9JUNtUyZynmXINTOmrZQ2NGEaZwnSSe7Bo3oRt2MNkMZF-Kef06Kq6kpquxeooUCiLGm2HrxyEmSfOB2j60sNqBTKq9WR7HUk0YtNp_uoNpx_TLjXWJVqfEVFlNI2RS0nHrxou2kAOkBX2uUlyjDcrXko0ginWxlhO1Bj3x4kHfPsqLXbUy7mLhU5lThCiPrkv598Coc0v-qAUA_2NqtL-wxh3ibrw24yS_qwPxqffj7ru5cl2H76IvvOt6n9Ncb2bDL7DXCxTJ8
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqogouiHcDCw1SKw4oqpPYjnNAaAtUW_o4baW9Gcdx2JVQUrpbVf1T_EZmHCdLEI9TLyvtelaOx-OZb5x5ELIrE5NZUbGIy9xGLDU6khoOns4Ey621YFZcgOyZmJyzzzM-2yA_ulwYDKvsdKJT1GVj8I58P8G6nXmc0Oz9xfcIu0bh29WuhUYrFsf25hpctuW7o4-wv3tJcvhp-mES-a4CkQHjuopKW0kjbVomVuuyAotmaao1NwDOga1c0yoRWlSIPkwO8i9EUWWVzLWg0sRY6ABU_h0wvBSdvWzWm2-ODRCFL8fW3vHEKXOpX4CiWCSliLvYe87x2oHuyxgNOBtYRdc8wGUIa_iue2OxNUc3_XrxJzD8e0znL0by8AG579FtOG7F8SHZsPUjstX2u7x5TPJTjR3D5qDDogMwn2U4delf4K2HAJ7DMaLRZgl_hc_FMlzH5jwh57fC5adks25qu01CZngKsIlzwcD3AX1RaQ5OfcmzogR5SAPytuOdMr6wOfbX-Kacg8O5Qk4rz-mA7PXUF21Bj7_QHeA29DRYhtv90Fx-Vf5UK0m1zZkoeVGAG1swbaW01NA8LTLwVHlAnvlNXM8Vg4eYwEPv4KaqNtu1VzNqLMAHl7jagLxxFKhoYDlG-3wJYAqW7BpQjgaUoCDMYHjXC85_FjzqpEp5PbZU61MXkNf9ME6AsXm1ba6AhoEh4FTkCSy3FcJ-IoDrWGMQlpsNxHPA1uFIvZi7KufYPQnQ7_N_P9YOuTuZnp6ok6Oz4xfkHi6ovSAbkc3V5ZV9CZBxVbxy5zQkX25bMfwEpl906Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3bbtMw1Jo6DfGCuC9QWJA28YCi5mI7zgNCLVu1MagmtEl7M47j0EooGWunab_G13GO46QEcXnaS6XWp3LO8bk650LIroh1anhJAyYyE9BEq0AoEDyVcpoZY8Cs2ATZGT88ox_O2fkG-dHWwmBaZasTraIuao135KMY-3ZmURymo9KlRZzsT99dfA9wghS-aW3HaTQscmxuriF8W7492oez3ovj6cHp-8PATRgINBjaVVCYUmhhkiI2ShUlWDcTJkoxDY46kJipsIy54iV6IjoDWeA8L9NSZIqHQkfY9ADU_2aKUdGAbE4OZiefW25mOA6Ru-ZszY1PlFBbCAY-FQ2E4FGbic8YXkKEIxGhOac9G2lHCdh6YQXfVWc6tuYYtF8v_uQa_57h-YvJnN4n95yv648b5nxANkz1kGw10y9vHpHsk8L5YXPQaMEEjGnhn9piMIjdfXCl_TH6pvUS_gqfi6W_ztR5TM5uhc5PyKCqK7NNfKpZAk4UY5xCJATao1QMQvyCpXkB3JF45E1LO6ldm3OctvFN2nCHMYmUlo7SHtnroC-a9h5_gZvgMXQw2JTb_lBffpVOxqUIlckoL1ieQ1CbU2WEMKEOsyRPIW5lHnnqDnG9VwTxYgwPvYOHKpva107pyDGHiFwgth55bSFQ7QA6WrnqCSAKNvDqQQ57kKAudG951zHOfxAetlwlnVZbyrUMeuRVt4wbYKZeZeorgKFgFljIsxjQbZiw2wicd-w4COimPfbskbW_Ui3mtuc5zlICX_jZvx9rh9wBpSA_Hs2On5O7iE9zWzYkg9XllXkB_uMqf-kE1Sdfbls3_AQDBHqE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Macrophage-Based+Therapies+for+Atherosclerosis+Management&rft.jtitle=Journal+of+immunology+research&rft.au=Peng%2C+Renyi&rft.au=Ji%2C+Hao&rft.au=Jin%2C+Libo&rft.au=Lin%2C+Sue&rft.date=2020&rft.pub=Hindawi&rft.issn=2314-8861&rft.eissn=2314-7156&rft.volume=2020&rft_id=info:doi/10.1155%2F2020%2F8131754&rft_id=info%3Apmid%2F32411803&rft.externalDocID=PMC7204102
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2314-8861&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2314-8861&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2314-8861&client=summon