Macrophage-Based Therapies for Atherosclerosis Management

• Published in: Journal of Immunology Research Vol. 2020; no. 2020; pp. 1 - 11
• Main Authors: Wu, Wei, Sun, Da, Xu, Ke, Huang, Yijiang, Lin, Sue, Jin, Libo, Ji, Hao, Peng, Renyi, Yang, Qinsi
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Animals; Apoptosis; Arteriosclerosis; Atherosclerosis; Atherosclerosis - drug therapy; Atherosclerosis - immunology; Autophagy; Autophagy - drug effects; Autophagy - immunology; Blood circulation disorders; Cardiovascular Agents - pharmacology; Cardiovascular Agents - therapeutic use; Cardiovascular disease; Cell Membrane - drug effects; Cell Membrane - immunology; Cerebrovascular diseases; Cholesterol; Coronary heart disease; Disease Models, Animal; Drug Carriers - pharmacology; Drug delivery systems; Drugs; Gene expression; Humans; Immunology; Inflammasomes - drug effects; Inflammasomes - immunology; Inflammation; Ischemia; Kinases; Lipids; Lipoproteins; Macrophage Activation - drug effects; Macrophage Activation - immunology; Macrophages; Macrophages - cytology; Macrophages - drug effects; Macrophages - immunology; Management; Oxidative stress; Pathogenesis; Phagocytosis; Proteins; Review; Vascular diseases; Vehicles; China
• ISSN: 2314-8861; 2314-7156; 2314-7156
• DOI: 10.1155/2020/8131754

Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient and safe management of AS. In this review, we focused on the systematical summary of the macrophage-based therapies in AS management, including macrophage autophagy, polarization, targeted delivery, microenvironment-triggered drug release, and macrophage- or macrophage membrane-based drug carrier. In conclusion, macrophage-based therapies have great promise to effectively manage AS in future research and clinic translation.