HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study

Background. Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. Material and Methods....

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Published inJournal of Diabetes Research Vol. 2017; no. 2017; pp. 1 - 4
Main Authors Lalèyè, Anatole, Baba Moussa, Lamine, Agbanlinsou, Arnaud, Ahoueya, Jocelyne, Osseni, Razack, Adjagba, Marius, Azonbakin, Simon, Medehouenou, Thierry C. Marc, Fagbemi, Kaossarath A., Darboux, Raphael
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Adolescent
Alleles
Benin - epidemiology
Case-Control Studies
Child
Child, Preschool
Confidence intervals
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - genetics
Diagnosis
DNA
Female
Gene Frequency
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Haplotypes
Health sciences
Histocompatibility Antigens Class II - genetics
HLA Antigens - genetics
HLA-DR4 Antigen - genetics
Humans
Insulin
Male
Pilot Projects
Studies
Type 1 diabetes
Benin
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Abstract Background. Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. Material and Methods. Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes. Results. Participants were aged 1–24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02. Conclusion. Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
AbstractList Background. Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. Material and Methods. Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes. Results. Participants were aged 1-24 years. T1D was significantly associated with DR3, DQA1 * 05:01, DQB1 * 02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1 * 03:02, and DQB1 * 06:02. Conclusion. Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes. Participants were aged 1-24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02. Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
BACKGROUNDSeveral studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D.MATERIAL AND METHODSClass II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes.RESULTSParticipants were aged 1-24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02.CONCLUSIONCertain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
Background. Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. Material and Methods. Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes. Results. Participants were aged 1–24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02. Conclusion. Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
Background . Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. Material and Methods . Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes. Results . Participants were aged 1–24 years. T1D was significantly associated with DR3, DQA1 ∗ 05:01, DQB1 ∗ 02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1 ∗ 03:02, and DQB1 ∗ 06:02. Conclusion . Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
Audience Academic
Author Medehouenou, Thierry C. Marc
Ahoueya, Jocelyne
Azonbakin, Simon
Darboux, Raphael
Fagbemi, Kaossarath A.
Lalèyè, Anatole
Baba Moussa, Lamine
Adjagba, Marius
Osseni, Razack
Agbanlinsou, Arnaud
AuthorAffiliation 2 Laboratoire de Recherche en Biologie Appliquée, Ecole Polytechnique d'Abomey-Calavi, Université d'Abomey-Calavi, Abomey-Calavi, Benin
3 Laboratoire de Biologie et de Typage Moléculaire en Microbiologie, Université d'Abomey-Calavi, Abomey-Calavi, Benin
1 UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin
AuthorAffiliation_xml – name: 3 Laboratoire de Biologie et de Typage Moléculaire en Microbiologie, Université d'Abomey-Calavi, Abomey-Calavi, Benin
– name: 1 UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin
– name: 2 Laboratoire de Recherche en Biologie Appliquée, Ecole Polytechnique d'Abomey-Calavi, Université d'Abomey-Calavi, Abomey-Calavi, Benin
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crossref_primary_10_3389_fpubh_2023_1014626
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Snippet Background. Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been...
Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in...
Background . Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been...
BACKGROUNDSeveral studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been...
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StartPage 1
SubjectTerms Adolescent
Alleles
Benin - epidemiology
Case-Control Studies
Child
Child, Preschool
Confidence intervals
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - genetics
Diagnosis
DNA
Female
Gene Frequency
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Haplotypes
Health sciences
Histocompatibility Antigens Class II - genetics
HLA Antigens - genetics
HLA-DR4 Antigen - genetics
Humans
Insulin
Male
Pilot Projects
Studies
Type 1 diabetes
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Title HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study
URI https://search.emarefa.net/detail/BIM-1174534
https://dx.doi.org/10.1155/2017/6053764
https://www.ncbi.nlm.nih.gov/pubmed/28808665
https://www.proquest.com/docview/2407637790
https://search.proquest.com/docview/1929107311
https://pubmed.ncbi.nlm.nih.gov/PMC5541783
https://doaj.org/article/4a57fff64465453ebcbadd979a23d9aa
Volume 2017
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