Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies

Background. Physical exercise (PE) has been associated with increase neuroplasticity, neurotrophic factors, and improvements in brain function. Objective. To evaluate the effects of different PE protocols on neuroplasticity components and brain function in a human and animal model. Methods. We condu...

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Published inJournal of neural transplantation & plasticity Vol. 2020; no. 2020; pp. 1 - 21
Main Authors Santos, Tony Meireles, Calazans, Camila Tenório, Santos, Lucas Eduardo R., Santos, Gabriela Carvalho Jurema, Ordônio, Tayrine Figueira, de Sousa Fernandes, Matheus Santos, Gomes, Dayane Aparecida
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 14.12.2020
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Analysis
Animals
Bias
Brain
Brain-derived neurotrophic factor
Exercise
Fitness equipment
Kinases
Neuroplasticity
Physical fitness
Review
Running
Systematic review
Tumor necrosis factor-TNF
Canada
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Summary:Background. Physical exercise (PE) has been associated with increase neuroplasticity, neurotrophic factors, and improvements in brain function. Objective. To evaluate the effects of different PE protocols on neuroplasticity components and brain function in a human and animal model. Methods. We conducted a systematic review process from November 2019 to January 2020 of the following databases: PubMed, ScienceDirect, SciELO, LILACS, and Scopus. A keyword combination referring to PE and neuroplasticity was included as part of a more thorough search process. From an initial number of 20,782 original articles, after reading the titles and abstracts, twenty-one original articles were included. Two investigators evaluated the abstract, the data of the study, the design, the sample size, the participant characteristics, and the PE protocol. Results. PE increases neuroplasticity via neurotrophic factors (BDNF, GDNF, and NGF) and receptor (TrkB and P75NTR) production providing improvements in neuroplasticity, and cognitive function (learning and memory) in human and animal models. Conclusion. PE was effective for increasing the production of neurotrophic factors, cell growth, and proliferation, as well as for improving brain functionality.
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Academic Editor: Grzegorz Hess
ISSN:2090-5904
0792-8483
1687-5443
1687-5443
DOI:10.1155/2020/8856621