Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes

• Published in: Journal of Diabetes Research Vol. 2018; no. 2018; pp. 1 - 6
• Main Authors: Zhang, Simin, Zhang, Xiuying, Ren, Qian, Zhu, Yu, Zhang, Rui, Chen, Ling, Gao, Xueying, Zhang, Fang, Wang, Yanai, Han, Xueyao, Ji, Linong, Liu, Wei, Li, Meng, Luo, Yingying, Zhou, Lingli, Cai, Xiaoling, Ma, Yumin, Gong, Siqian, Huang, Xiuting, Zhou, Xianghai
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adolescent; Adult; Aged; Body mass index; Case-Control Studies; China; Cholesterol; Chronic illnesses; Circulating MicroRNA - blood; Circulating MicroRNA - genetics; Comparative analysis; Creatinine; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; DNA, Mitochondrial - genetics; Enzymes; Female; Gene expression; Genetic aspects; Genetic Markers; Genetic Predisposition to Disease; Genetic Variation; Glucokinase - genetics; Glucose; Hepatocyte Nuclear Factor 1-alpha - genetics; Humans; Hyperglycemia; Hypertension; Isoenzymes; Lipids; Liver; Male; Metabolism; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; Mutation; Peptides; Phenotype; Physiological aspects; Plasma; Risk Factors; Standard deviation; Transcription factors; Type 1 diabetes; Type 2 diabetes; Young Adult; United States > US; China
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2018/7842064

miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). In total, 12 HNF1A-DM patients, 24 gender-, age-, and body mass index-matched (1 : 2) T2DM patients and 24 healthy subjects were included in this study. In addition, 30 monogenic diabetes (11 GCK-DM and 19 MDM) and 17 T1DM patients were included. Fasted blood biochemistry and miR-122 were measured. The results showed that the HNF1A-DM patients had lower miR-122 levels [0.046 (0.023, 0.121)] than T2DM patients [0.165 (0.036, 0.939), P=0.02] and healthy controls [0.249 (0.049, 1.234), P=0.019]. The area under the curve of the receiver operating characteristic curve for miR-122 to discriminate HNF1A-DM and T2DM was 0.687 (95% CI: 0.52–0.86, P=0.07). There was no difference in serum miR-122 among HNF1A-DM, GCK-DM, MDM, and T1DM patients. Lower serum miR-122 is a unique feature of HNF1A-DM patients and might partially explain the increased risk for liver neoplasm and abnormal lipid metabolism in HNF1A-DM patients.