The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression

• Published in: Journal of Immunology Research Vol. 2020; no. 2020; pp. 1 - 9
• Main Authors: Ma, Fang, Feng, Ying, Jiang, Fangfei, Yu, Lin, Zhang, Yue, Su, Dongmei, Ma, Xue, Zheng, Yayun, Zhou, Xue
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Amino acids; Antigens, CD - chemistry; Antigens, CD - genetics; Antigens, CD - metabolism; Antigens, CD - physiology; Antigens, Differentiation, Myelomonocytic - chemistry; Antigens, Differentiation, Myelomonocytic - genetics; Antigens, Differentiation, Myelomonocytic - metabolism; Antigens, Differentiation, Myelomonocytic - physiology; Antiviral agents; Apoptosis; Arthritis; B cells; Binding sites; Cloning; Cytotoxicity; Dendritic cells; Development and progression; Disease Progression; Health aspects; Humans; Immune response; Immunology; Immunotherapy; Infection; Infections; Killer cells; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lectins; Lectins - chemistry; Lectins - genetics; Lectins - metabolism; Lectins - physiology; Ligands; Lymphocytes; Natural killer cells; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Neutrophils; Peptides; Proteins; Review; Sialic Acid Binding Immunoglobulin-like Lectins - chemistry; Sialic Acid Binding Immunoglobulin-like Lectins - genetics; Sialic Acid Binding Immunoglobulin-like Lectins - metabolism; Sialic Acid Binding Immunoglobulin-like Lectins - physiology; Signal transduction; Tumors; Virus diseases; Virus Diseases - immunology; Virus Diseases - metabolism; Virus Diseases - pathology; China
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2020/6243819

The function of natural killer (NK) cells, defending against virus infection and tumour progression, is regulated by multiple activating and inhibiting receptors expressed on NK cells, among which sialic acid-bind immunoglobulin-like lectins (Siglecs) act as a vital inhibitory group. Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands. Siglec7 and Siglec9 are very similar in distribution, gene encoding, protein sequences, ligand affinity, and functions in regulating the immune system against virus and cancers, but differences still exist between them. In this review, we aim to discuss the similarities and differences between Siglec7 and Siglec9 and analyze their functions in virus infection and tumour progression in order to develop better anti-viral and anti-tumor immunotherapy in the future.