Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries. Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flaviv...

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Published inJournal of Immunology Research Vol. 2018; no. 2018; pp. 1 - 7
Main Authors Guo, Hong-Yan, Jia, Renyong, Zhang, Xing-Cui
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Wiley
Subjects
Animals
Cytokines
Dengue fever
Dengue virus
Encephalitis
Flavivirus
Gene expression
Immunology
Infections
Innate immunity
Interferon
Kinases
Mammals
Pathogens
Pattern recognition receptors
Proteins
Retinoic acid
Review
RNA viruses
Toll-like receptors
Vaccines
Viruses
West Nile virus
China
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Summary:Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries. Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flavivirus infections yet. Innate immunity is the first line of defense in resisting pathogen invasion, serving an important role in a resisting virus. Toll-like receptors (TLRs) and retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) are crucial pattern recognition receptors (PRRs) that play essential roles in recognizing and clearing pathogens, including resisting flavivirus. In the present review, we provide a significant reference for further research on the function of innate immunity in resisting flavivirus.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Academic Editor: Tomasz Baczek
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/6106582