Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations

• Published in: Vaccine Vol. 29; no. 51; pp. 9499 - 9507
• Main Authors: Juul-Madsen, Helle R, Norup, Liselotte R, Jørgensen, Poul H, Handberg, Kurt J, Wattrang, Eva, Dalgaard, Tina S
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 28.11.2011; Elsevier; Elsevier Limited
• Subjects: Adaptive Immunity; Allergy and Immunology; Animals; Applied microbiology; Autoimmune diseases; Bacterial infections; Biological and medical sciences; blood serum; Challenge response; Chicken; Chickens; Chickens - immunology; Chickens - virology; Coronavirus Infections - immunology; Coronavirus Infections - veterinary; Disease; Fundamental and applied biological sciences. Psychology; genome; Immune response; Immune system; Immunity, Innate; Infections; Infectious bronchitis; Infectious bronchitis virus; Infectious bronchitis virus - immunology; Infectious bronchitis virus - pathogenicity; inflammation; Lectins; mannose; Mannose - pharmacology; Mannose-binding lectin (MBL); Mannose-Binding Lectin - blood; Microbiology; Miscellaneous; pathogens; Poultry; Poultry Diseases - immunology; Receptors, Pattern Recognition; respiratory system; Respiratory System - immunology; Respiratory System - virology; Respiratory tract; Studies; T-lymphocytes; T-Lymphocytes - immunology; vaccination; Vaccination - veterinary; Vaccine response; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral Vaccines - administration & dosage; Viral Vaccines - immunology; Virology; viruses; Vaccine response; Mannose-binding lectin (MBL); Infectious bronchitis; Chicken; Challenge response; Lectin; Poultry; Vaccination; Natural immunity; Mannose; Bronchus disease; Serum; Bronchitis; Aves; Coronaviridae; Farming animal; Immune response; Respiratory disease; Vaccine; Avian infectious bronchitis virus; Virus; Vertebrata; Coronavirus; Veterinary; Nidovirales
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.10.016

Highlights ► Serum MBL levels influence the ability of chickens to clear the respiratory tract for virus genomes after an infectious bronchitis virus (IBV) infection. ► Serum levels influence IBV vaccine-induced changes in circulating T-cell populations. ► Addition of mannose to a IBV vaccine alter the vaccine-induced immune response.