Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder

• Published in: Journal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 1 - 8
• Main Authors: Wang, Fei, Geng, Haiyang, Chang, Miao, Kong, Lingtao, Tang, Yanqing, Gong, Xiaohong, Cui, Lingling, Xu, Ke
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Wiley
• Subjects: Adolescent; Adult; Age; Brain - diagnostic imaging; Brain - physiology; Data processing; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - genetics; Education; Female; Genes; Genetic aspects; Genome-Wide Association Study - methods; Genomes; Genomics; Genotype & phenotype; Humans; Illnesses; Inorganic Pyrophosphatase - genetics; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Major depressive disorder; Male; Mental depression; Middle Aged; Monte Carlo simulation; Polymorphism, Single Nucleotide - genetics; Rest - physiology; Single nucleotide polymorphisms; Thyroid gland; Variance analysis; Young Adult; China

A single-nucleotide polymorphism at the LHPP gene (rs35936514) has been reported in genome-wide association studies to be associated with major depressive disorder (MDD). However, the neural system effects of rs35936514 that mediate the association are unknown. The present work explores whether the...