Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder

• Published in: Journal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 1 - 8
• Main Authors: Wang, Fei, Geng, Haiyang, Chang, Miao, Kong, Lingtao, Tang, Yanqing, Gong, Xiaohong, Cui, Lingling, Xu, Ke
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Wiley
• Subjects: Adolescent; Adult; Age; Brain - diagnostic imaging; Brain - physiology; Data processing; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - genetics; Education; Female; Genes; Genetic aspects; Genome-Wide Association Study - methods; Genomes; Genomics; Genotype & phenotype; Humans; Illnesses; Inorganic Pyrophosphatase - genetics; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Major depressive disorder; Male; Mental depression; Middle Aged; Monte Carlo simulation; Polymorphism, Single Nucleotide - genetics; Rest - physiology; Single nucleotide polymorphisms; Thyroid gland; Variance analysis; Young Adult; China
• ISSN: 2090-5904; 0792-8483; 1687-5443; 1687-5443
• DOI: 10.1155/2016/9162590

A single-nucleotide polymorphism at the LHPP gene (rs35936514) has been reported in genome-wide association studies to be associated with major depressive disorder (MDD). However, the neural system effects of rs35936514 that mediate the association are unknown. The present work explores whether the LHPP rs35936514 polymorphism moderates brain regional activity in MDD. A total of 160 subjects were studied: a CC group homozygous for the C allele (23 individuals with MDD and 57 controls) and a T-carrier group carrying the high risk T allele (CT/TT genotypes; 22 MDD and 58 controls). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Brain activity was assessed using the amplitudes of low-frequency fluctuations (ALFF). MDD patients showed a significant increased ALFF in the left middle temporal gyrus and occipital cortex. The T-carrier group showed increased ALFF in the left superior temporal gyrus. Significant diagnosis × genotype interaction was noted in the bilateral lingual gyri, bilateral dorsal lateral prefrontal cortex (dlPFC), and left medial prefrontal cortex (mPFC) (P<0.05, corrected). Results demonstrated that MDD patients with LHPP rs35936514 CT/TT genotype may influence the regional brain activity. These findings implicate the effects of the rs35936514 variation on the neural system in MDD.