The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders: Current Progress and Future Challenges

Vascular disorders are complex diseases with high morbidity and mortality. Among them, the dilated macrovascular diseases (MVD), such as aortic aneurysm and aortic dissection, have presented a huge threat to human health. The pathogenesis of vascular diseases is mostly associated with property alter...

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Published inStem cells international Vol. 2019; no. 2019; pp. 1 - 9
Main Authors Huang, Haoyue, Wang, Ying, Li, Jingjing, Lin, Yang, Peng, Guang-Yin, Shen, Zhenya
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Aneurysms
Aortic dissection
Blood
Critical care
Disease
Diseases
Disorders
Efficiency
Endothelial cells
Fibroblasts
Gene expression
Gene therapy
Genes
Genetic research
Growth factors
Health aspects
Health risks
Marfan syndrome
Medicine
Methods
Morbidity
Mortality
Muscles
Pathogenesis
Pluripotency
Pulmonary hypertension
Researchers
Review
Skin
Smooth muscle
Somatic cells
Stem cell research
Stem cells
Transplantation
Vascular diseases
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Summary:Vascular disorders are complex diseases with high morbidity and mortality. Among them, the dilated macrovascular diseases (MVD), such as aortic aneurysm and aortic dissection, have presented a huge threat to human health. The pathogenesis of vascular diseases is mostly associated with property alteration of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs). Studies have confirmed that induced pluripotent stem cells (iPSCs) can be proliferated and differentiated into other somatic cells, such as VECs and VSMCs. And patient-specific cells could provide detailed human-associated information in regard to pathogenesis or drug responses. In addition, differentiated ECs from iPSC have been widely used in disease modeling as a cell therapy. In this review, we mainly discussed the application of hiPSCs in investigating the pathological mechanism of different inherited vascular diseases and provide a comprehensive understanding of hiPSCs in the field of clinical diagnosis and gene therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Academic Editor: Diana Klein
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2019/9613258