Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

• Published in: Journal of Diabetes Research Vol. 2017; no. 2017; pp. 1 - 8
• Main Authors: Macdonald, Ian A., Stephens, Francis B., Mansell, Peter, Gaffney, Christopher J., Tsintzas, Kostas
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; Hindawi Limited; Wiley
• Subjects: Age; Arthritis; Blood Glucose - metabolism; Body Mass Index; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetic retinopathy; Disease; Energy metabolism; Energy Metabolism - drug effects; Energy Metabolism - physiology; Exercise; Exercise - physiology; Female; Food; Glucose; Glycemic index; Health aspects; Heart rate; Humans; Hypoglycemia; Insulin; Insulin - pharmacology; Laboratories; Male; Metabolism; Middle Aged; Oxygen Consumption - drug effects; Oxygen Consumption - physiology; Physical fitness; Potassium; Type 2 diabetes; Workloads; United Kingdom > UK; United States > US
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2017/8248725

This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P<0.0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l). This was associated with a lower (P<0.05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P<0.01), which was accompanied by a lower blood lactate response (P<0.05). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization.