A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder

This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5–20 Hz band during 0.2–1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language fun...

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Bibliographic Details
Published inJournal of autism and developmental disorders Vol. 49; no. 8; pp. 3181 - 3190
Main Authors Bloy, Luke, Shwayder, Kobey, Blaskey, Lisa, Roberts, Timothy P. L., Embick, David
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2019
Springer
Springer Nature B.V
Subjects
Analysis
Auditory stimulation
Auditory Stimuli
Autism
Autistic children
Behavioral Science and Psychology
Brain
Brain activity
Brain Hemisphere Functions
Child and School Psychology
Children
Clinical assessment
Cognitive Ability
Evoked potentials (Electrophysiology)
Health aspects
Language
Language acquisition
Language disorders
Language Impairments
Language Skills
Mental lexicon
Native language acquisition
Neurosciences
Original Paper
Pediatrics
Pervasive Developmental Disorders
Psychology
Public Health
Severity
Severity (of Disability)
Symptoms (Individual Disorders)
Synchronization
Magnetoencephalography (MEG)
Language impairment
Oscillation
Lexical access
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Summary:This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5–20 Hz band during 0.2–1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. The measure does not appear related to general cognitive ability nor autism symptom severity (beyond degree of language impairment). We suggest that this oscillatory brain activity indexes lexical search and thus increases with increased search in the mental lexicon. While specificity for language impairment in ASD remains to be determined, such an objective index has potential utility in low functioning individuals with ASD and young children during language acquisition.
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Luke Bloy, Ph.D. is a Research Scientist at the Lurie Family Foundations MEG Imaging Center at the Children’s Hospital of Philadelphia (CHOP). Kobey Shwayder, Ph.D. is a Post-Doctoral Researcher in the Radiology Department at CHOP and a Visiting Scholar in the Department of Linguistics at the University of Pennsylvania. Lisa Blaskey, PhD, is a pediatric neuropsychologist in the Department of Child and Adolescent Psychiatry and Behavioral Sciences, the Center for Autism Research, and the Autism Integrated Care Program at CHOP. Timothy P.L. Roberts, PhD, is a professor of Radiology, Vice-chair of Research for the Department of Radiology and the Oberkircher Family Endowed Chair in Pediatric Radiology at CHOP. David Embick, Ph.D. is a professor and chair of the Department of Linguistics at the University of Pennsylvania.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-019-04040-x