Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency

• Published in: Cardiology research and practice Vol. 2019; no. 2019; pp. 1 - 10
• Main Authors: Maestrini, Viviana, Mancone, Massimo, Fedele, Francesco, Pucci, Mariateresa, Infusino, Fabio, Scarpati, Rossana, D’Amato, Andrea, Maraone, Annalisa, Mariani, Marco Valerio, Netti, Lucrezia, Severino, Paolo, Lavalle, Carlo
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2019; Hindawi; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Adenosine triphosphate; Anticoagulants; Arrhythmia; Binding sites; Blood platelets; Blood pressure; Cardiovascular system; Coronary heart disease; Coronary vessels; Diabetes; Endothelium; Enzymes; Glucose; Heart; Homeostasis; Hypertension; Inflammation; Insulin; Ischemia; Lipids; Lipoproteins; Magnesium deficiency diseases; Medical screening; Metabolic syndrome; Nitric oxide; Physiology; Prevention; Review; Signal transduction; Type 2 diabetes
• ISSN: 2090-8016; 2090-0597; 2090-0597
• DOI: 10.1155/2019/4874921

Magnesium is an essential mineral naturally present in the human body, where it acts as cofactor in several enzymatic reactions. Magnesium is a key cardiovascular regulator, which maintains electrical, metabolic, and vascular homeostasis. Moreover, magnesium participates in inflammation and oxidative processes. In fact, magnesium deficiency is involved in the pathophysiology of arterial hypertension, diabetes mellitus, dyslipidemia, metabolic syndrome, endothelial dysfunction, coronary artery disease, cardiac arrhythmias, and sudden cardiac death. In consideration of the great public-health impact of cardiovascular disease, the recognition of the negative effects of magnesium deficiency suggests the possible role of hypomagnesaemia as cardiovascular risk factor and the use of serum magnesium level for the screening and prevention of cardiovascular risk factors and cardiovascular diseases. Moreover, it might help with the identification of new therapeutical strategies for the management of cardiovascular disease through magnesium supplementation.