Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration

• Published in: Scientific reports Vol. 11; no. 1; pp. 19987 - 9
• Main Authors: Hirai, Hiromasa, Yamashita, Mariko, Matsumoto, Masanori, Hayakawa, Masaki, Sakai, Kazuya, Ueda, Tetsuo, Ogata, Nahoko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.10.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/420; 692/699; Age; Aged; Aged, 80 and over; Choroidal Neovascularization - blood; Choroidal Neovascularization - genetics; Choroidal Neovascularization - pathology; Complement factor H; Complement Factor H - analysis; Complement Factor H - genetics; Cross-Sectional Studies; Female; Gene polymorphism; Humanities and Social Sciences; Humans; Japan; Macular degeneration; Macular Degeneration - blood; Macular Degeneration - genetics; Macular Degeneration - pathology; Male; multidisciplinary; Patients; Polymorphism, Genetic; Retinal Hemorrhage; Science; Science (multidisciplinary); Thromboembolism; Thrombosis; Von Willebrand factor; von Willebrand Factor - analysis; von Willebrand Factor - genetics; Japan
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-99557-6

Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H ( CFH ). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH . PNV group was significantly younger than AMD group ( P  = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V . The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD ( P  = 0.045, P  = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD.