Prostate cancer risk prediction models in Eastern Asian populations: current status, racial difference, and future directions

• Published in: Asian journal of andrology Vol. 22; no. 2; pp. 158 - 161
• Main Authors: He, Bi-Ming, Chen, Rui, Sun, Tian-Qi, Yang, Yue, Zhang, Chun-Lei, Ren, Shan-Cheng, Gao, Xu, Sun, Ying-Hao
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer India Pvt. Ltd 01.03.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Accuracy; Advantages; Age; Aged; Antigens; Asian people; asians; nomogram; prediction models; prostate cancer; risk prediction; Calibration; Cancer prevention; Cancer research; Clinical trials; Early Detection of Cancer; Family medical history; Far East; Humans; Male; Middle Aged; Models, Theoretical; Prevention; Probability; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Researchers; Review; Risk Assessment; Risk Factors; Studies; Far East; South Korea; China; Asia; prediction models; prostate cancer; nomogram; risk prediction; Asians
• ISSN: 1008-682X; 1745-7262
• DOI: 10.4103/aja.aja_55_19

Prostate cancer (PCa) risk calculators (RCs) with prostate-specific antigen (PSA) and other risk factors can greatly improve the accurate prediction of potential risk of PCa compared to PSA. The European Randomized Study of Screening for PCa Risk Calculator (ERSPC-RC) and the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) are developed on the Western population. However, the Western RCs showed limited diagnostic efficacy in the Eastern Asian population, mainly due to racial differences between the two populations. We aimed to review the application of Western RCs and Eastern Asian RCs in Eastern Asian cohorts and to identify the characteristics and efficacy of these RCs.