Cs 2 CO 3 -Catalyzed Rauhut-Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[ b ]oxepin Derivatives

The synthesis of fused benzoxepines relies on the use of complex substrates and methodologies. Herein, we report our experimental and theoretical findings about an unprecedented Rauhut-Currier-type reaction catalyzed by Cs CO to access these important compounds. The developed methodology avoids the...

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Bibliographic Details
Published inJournal of organic chemistry
Main Authors López, Roger, Jamis-Oliva, Omar, Lühr, Susan, Galdámez, Antonio, Gallardo-Fuentes, Sebastián, Vilches-Herrera, Marcelo
Format Journal Article
LanguageEnglish
Published United States 29.10.2024
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Summary:The synthesis of fused benzoxepines relies on the use of complex substrates and methodologies. Herein, we report our experimental and theoretical findings about an unprecedented Rauhut-Currier-type reaction catalyzed by Cs CO to access these important compounds. The developed methodology avoids the use of phosphine- or amine-based catalysts and additives. The reaction can be performed under microwave irradiation and proceeds with complete chemoselectivity.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.4c01544