Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

Michalina Gora and her colleagues have developed a tethered capsule endoscope in the form of a swallowable pill that does not require sedation and is the size of a one-cent coin. Once swallowed, the device was well tolerated and used to capture three-dimensional microstructural images of the digesti...

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Bibliographic Details
Published inNature medicine Vol. 19; no. 2; pp. 238 - 240
Main Authors Gora, Michalina J, Sauk, Jenny S, Carruth, Robert W, Gallagher, Kevin A, Suter, Melissa J, Nishioka, Norman S, Kava, Lauren E, Rosenberg, Mireille, Bouma, Brett E, Tearney, Guillermo J
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.02.2013
Nature Publishing Group
Subjects
692/699/1503
692/700/1421/164/2224
Barrett Esophagus - diagnostic imaging
Biomedicine
Cancer Research
Capsule Endoscopy - methods
Endoscopic surgery
Gastrointestinal diseases
Gastrointestinal Diseases - diagnosis
Gastrointestinal system
Gastrointestinal tract
Gastrointestinal Tract - ultrastructure
Humans
Infectious Diseases
Medical imaging
Metabolic Diseases
Microscopy
Microstructure
Molecular Medicine
Neurosciences
technical-report
Ultrasonography
United States
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Summary:Michalina Gora and her colleagues have developed a tethered capsule endoscope in the form of a swallowable pill that does not require sedation and is the size of a one-cent coin. Once swallowed, the device was well tolerated and used to capture three-dimensional microstructural images of the digestive tract, particularly the esophagus, using optical frequency domain imaging. Feasibility was demonstrated in patients with Barrett’s esophagus, including high-grade dysplasia. Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
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ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/nm.3052