Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial

• Published in: International Journal of Obesity Vol. 43; no. 9; pp. 1863 - 1868
• Main Authors: Pedret, Anna, Valls, Rosa M., Calderón-Pérez, Lorena, Llauradó, Elisabet, Companys, Judit, Pla-Pagà, Laura, Moragas, Ana, Martín-Luján, Francisco, Ortega, Yolanda, Giralt, Montse, Caimari, Antoni, Chenoll, Empar, Genovés, Salvador, Martorell, Patricia, Codoñer, Francisco M., Ramón, Daniel, Arola, Lluís, Solà, Rosa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2019; Nature Publishing Group
• Subjects: 59/57; 692/499; 692/699/1702/393; Adipose tissue; Adiposity - physiology; Adult; Anthropometry; Bifidobacterium animalis; Biomarkers; Blood pressure; Body mass index; Body measurements; Body size; Brief Communication; Epidemiology; Female; Health Promotion and Disease Prevention; Health risk assessment; Humans; Ingestion; Internal Medicine; Intestinal microflora; Male; Maltodextrin; Medicine; Medicine & Public Health; Metabolic Diseases; Microbiomes; Obesity; Obesity, Abdominal - diet therapy; Obesity, Abdominal - physiopathology; Probiotics; Probiotics - administration & dosage; Probiotics - therapeutic use; Public Health; Randomization; Waist Circumference - physiology; Spain
• ISSN: 0307-0565; 1476-5497; 1476-5497
• DOI: 10.1038/s41366-018-0220-0

Background The effects of probiotic Bifidobacterium animalis subsp . lactis CECT 8145 (Ba8145) and those of its heat-killed form (h-k Ba8145) on human anthropometric adiposity biomarkers are unknown. Objective To assess the effect of Ba8145 and h-k Ba8145 ingestion on anthropometric adiposity biomarkers. Design Randomized, parallel, double-blind, placebo-controlled trial with abdominally obese individuals. Participants ( n  = 135) consumed 1 capsule/day containing 10 10 colony forming unit (CFU) of Ba8145, 10 10 CFU of h-k Ba8145, or placebo (maltodextrin) for 3 months. Results Ba8145 ingestion decreased waist circumference, waist circumference/height ratio, and Conicity index ( P  < 0.05) versus its baseline. Changes versus the placebo group reached significance ( P  < 0.05) after the h-k Ba8145 treatment. Ba8145 decreased the body mass index compared with baseline and placebo group ( P  < 0.05). The decrease in visceral fat area after Ba8145 treatments reached significance ( P  < 0.05) only after h-k Ba8145. When analyses by gender were performed, significance remained only for women. Diastolic blood pressure and HOMA index decreased ( P  < 0.05) after h-k Ba8145. Gut microbiome analyses showed an increase in Akkermansia spp. after Ba8145 treatment, particularly in the live form, which was inversely related to weight ( P  = 0.003). Conclusions In abdominally obese individuals, consumption of Ba8145, both as viable and mainly as heat-killed cells, improves anthropometric adiposity biomarkers, particularly in women. An increase in the gut Akkermansia genus appears as a possible mechanism involved. Our results support Ba8145 probiotic as a complementary strategy in obesity management.