Bioavailability of selenium from bovine milk as assessed in subjects with ileostomy

• Published in: European journal of clinical nutrition Vol. 58; no. 2; pp. 350 - 355
• Main Authors: Chen, J, Lindmark-Mansson, H, Drevelius, M, Tidehag, P, Hallmans, G, Hertervig, E, Nilsson, A, Akesson, B
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01.02.2004; Nature Publishing Group
• Subjects: Absorption; Adult; Agricultural research; Animals; Beverages; Bioavailability; Biological and medical sciences; Biological Availability; Clinical nutrition; Cow's milk; Cultured Milk Products - metabolism; Dairy farms; Diet; Dietary Fats; Female; fermentation; Fermented milk products; Fundamental and applied biological sciences. Psychology; Health Sciences; Humans; Hälsovetenskap; Ileostomy; Intestinal Absorption; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Metabolisms and neurohumoral controls; Middle Aged; Milk; Milk - chemistry; Milk - metabolism; Milk/chemistry/metabolism; Minerals; Nutrition and Dietetics; Näringslära; Ostomy; Pilot Projects; Selenium; Selenium - administration & dosage; Selenium - pharmacokinetics; selenium bioavailability; Selenium/administration & dosage/pharmacokinetics; selenoprotein; Soft drinks; Studies; Sweden; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Water and mineral metabolism. Osmoregulation. Acidobasic balance; Sweden; Europe; Ileostomy; Meal; Absorption; Female; Soft drink; Ambulatory; Hospital; Selenium; Ungulata; Human; Addition; Bovine; Nutrition; selenium bioavailability; milk; Bioavailability; Feeding; Medicine; selenoprotein; Vertebrata; Mammalia; Diet; University; Human milk; fermentation; Artiodactyla
• ISSN: 0954-3007; 1476-5640; 1476-5640
• DOI: 10.1038/sj.ejcn.1601789

Objective: To assess the absorption of dietary selenium in humans, especially of milk selenium. Design: 1-day meal studies in subjects with ileostomy. Setting: Hospital outpatient clinics. Subjects: Three subjects in the pilot study and nine subjects in the main study (eight men/ four women). Intervention: Different beverages, 1 l/day, were given in addition to basal diets (soft drink, 1 week; low-fat milk, 3 weeks; fermented low-fat milk, 3 weeks and soft drink, 1 week). Ileostomy effluents were collected during the last 2 days in each of the four periods. Results: On days when the subjects were given 1 l of low-fat milk, the estimated fractional absorption of total dietary selenium was 65.5 (2.3)% (mean (s.d.), n=18), which was similar to the value when fermented low-fat milk was given (64.1 (3.2)%). However, both the calculated amount of milk selenium absorbed (10.9 (2.4) vs 9.4 (1.7) microgram selenium) and its fractional absorption (73.3 (16.1) vs 64.1 (11.2)%, n=18) were significantly higher for milk than for fermented milk. Conclusions: Selenium from milk and other sources is well absorbed in subjects with ileostomy. The real absorption may be even higher than the values shown.