Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes

• Published in: Genes and immunity Vol. 10; no. S1; pp. S60 - S63
• Main Authors: Kahles, H, Morahan, G, Todd, J A, Badenhoop, K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2009; Nature Publishing Group
• Subjects: Alfacalcidol; Association analysis; Autoimmune diseases; Beta cells; Biomedical and Life Sciences; Biomedicine; Calcifediol; Cancer Research; Cell receptors; Consortia; Data processing; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Environmental factors; Female; Gene Expression; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetic susceptibility; Genetics; Genotype; Health aspects; Histocompatibility antigen HLA; HLA-DQ Antigens - genetics; HLA-DQ Antigens - immunology; HLA-DR Antigens - genetics; HLA-DR Antigens - immunology; Hormones; Human Genetics; Humans; Immunology; Insulin; Male; Nuclear Family; Nutrient deficiency; original-article; Pancreas; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Progeny; Receptors, Calcitriol - genetics; Risk factors; Single-nucleotide polymorphism; Type 1 diabetes; Vitamin D; Vitamin D receptors; Vitamin deficiency; United Kingdom; United Kingdom > UK; North America; Europe; Germany; genetic susceptibility; single nucleotide polymorphism; autoimmune disease; type I diabetes; vitamin D
• ISSN: 1466-4879; 1476-5470; 1476-5470
• DOI: 10.1038/gene.2009.93

Type I diabetes (T1D) results from interactions between environmental exposures and genetic susceptibility leading to immune dysfunction and destruction of the insulin-producing β cells of the pancreas. Vitamin D deficiency is likely to be one of the many environmental factors influencing T1D development and diagnosis, and, hence, the hormone receptor gene, VDR, was examined for association with T1D risk. The Type I Diabetes Genetics Consortium genotyped 38 single nucleotide polymorphisms (SNPs) in 1654 T1D nuclear families (6707 individuals, 3399 affected). Genotypes for 38 SNPs were assigned using the Illumina (ILMN) and Sequenom (SQN) technology. The analysis of data release as of July 2008 is reported for both platforms. No evidence of association of VDR SNPs with T1D at P <0.01 was obtained in the overall sample set, nor in subgroups analyses of the parent-of-origin, sex of offspring and HLA risk once adjusted for multiple testing.