Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus

• Published in: Journal of Veterinary Medical Science Vol. 75; no. 8; pp. 1085 - 1089
• Main Authors: HARA, Yuka, SUZUKI, Junko, NOGUCHI, Keita, TERADA, Yutaka, SHIMODA, Hiroshi, MIZUNO, Takuya, MAEDA, Ken
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2013; Japan Science and Technology Agency
• Subjects: Amino Acid Sequence; Animals; Antigens, CD - genetics; Antigens, CD - metabolism; Base Sequence; canine distemper virus; Cats; Cluster Analysis; Distemper Virus, Canine - physiology; DNA Primers - genetics; feline; Feline Panleukopenia - physiopathology; Feline Panleukopenia - virology; Flow Cytometry; Molecular Sequence Data; Phylogeny; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Virus - metabolism; Sequence Analysis, DNA; signaling lymphocyte activation molecule; Signaling Lymphocytic Activation Molecule Family Member 1; Species Specificity; Virus Internalization
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.13-0003

Morbilliviruses use signaling lymphocyte activation molecule (SLAM) as a receptor for their entry to cells. In this study, a complete gene encoding SLAM of a domestic cat was identified. The identity of feline SLAM with canine one was 73%, and feline SLAM formed the same cluster with those of carnivores. Furthermore, feline cell expressing feline SLAM supported growth of canine distemper virus (CDV) as well as that expressing canine one. These results indicated that feline SLAM can function as a receptor for morbilliviruses, and our established feline cells that express feline SLAM might be useful for analysis of morbilliviruses originated from felids.