Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis

• Published in: Particle and fibre toxicology Vol. 18; no. 1; pp. 6 - 15
• Main Authors: Annangi, Balasubramanyam, Lu, Zhuyi, Bruniaux, Jonathan, Ridoux, Audrey, da Silva, Vanessa Marques, Vantelon, Delphine, Boczkowski, Jorge, Lanone, Sophie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.02.2021; BioMed Central; BMC
• Subjects: Alveolar fibrosis - autophagy - macrophage polarization; Alveoli; Animals; Autophagy; Autophagy (Cytology); Cerium; Cerium - toxicity; Cerium oxides; Collagen; Collagen (type I); Exposure; Fibrosis; Genotype & phenotype; Granuloma; Health aspects; Human health and pathology; Infiltration; Inflammation; Life Sciences; Lung; Lung diseases; Lungs; Macrophages; Metallic oxides; Mice; Nanoparticle; Nanoparticles; Nanoparticles - toxicity; Oxidation; Phagocytosis; Phenotypes; Physiological aspects; Physiology; Pneumoconiosis; Prevention; Proteins; Pulmonary Fibrosis - chemically induced; Pulmonology and respiratory tract; Rare earth elements; Risk factors; Transforming growth factor-b1; France; Nanoparticle; Alveolar fibrosis - autophagy - macrophage polarization

Cerium (Ce) is a rare earth element, rapidly oxidizing to form CeO , and currently used in numerous commercial applications, especially as nanoparticles (NP). The potential health effects of Ce remain uncertain, but literature indicates the development of rare earth pneumoconiosis accompanied with g...