Of von Willebrand factor and platelets

Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platel...

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Published inCellular and molecular life sciences : CMLS Vol. 72; no. 2; pp. 307 - 326
Main Authors Bryckaert, Marijke, Rosa, Jean-Philippe, Denis, Cécile V, Lenting, Peter J
Format Journal Article
LanguageEnglish
Published Basel Springer-Verlag 01.01.2015
Springer Basel
Springer Nature B.V
Subjects
adhesion
animal models
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
blood coagulation factors
blood platelets
cell adhesion
Cell Biology
Glycoproteins
Glycoproteins - metabolism
Hemostasis - physiology
integrins
Life Sciences
Mice
Models, Biological
Neurons
Pathology
platelet activation
Platelet Adhesiveness - physiology
Platelet Aggregation - physiology
Protein Structure, Tertiary
receptors
Review
Thrombosis
Thrombosis - physiopathology
von Willebrand Factor - genetics
von Willebrand Factor - metabolism
Glycoprotein Ib-IX-V
Platelets
Hemostasis
Thrombosis
von Willebrand factor
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Summary:Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 integrin, in promoting primary platelet adhesion and aggregation following vessel injury. This review will recapitulate our current knowledge on the subject from the rheological aspect to the spatio-temporal development of thrombus formation. We will also discuss the signaling events generated by VWF/GPIb-IX-V interaction, leading to platelet activation. Additionally, we will review the growing body of evidence gathered from the recent development of pathological mouse models suggesting that VWF binding to GPIb-IX-V is a promising target in arterial and venous pathological thrombosis. Finally, the pathological aspects of VWF and its impact on platelets will be addressed.
Bibliography:http://dx.doi.org/10.1007/s00018-014-1743-8
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ObjectType-Review-1
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-014-1743-8