The influence of body mass index on the accumulation of advanced glycation end products in hemodialysis patients

• Published in: European journal of clinical nutrition Vol. 69; no. 3; pp. 309 - 313
• Main Authors: Arsov, S, Trajceska, L, van Oeveren, W, Smit, A J, Dzekova, P, Stegmayr, B, Sikole, A, Rakhorst, G, Graaff, R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2015; Nature Publishing Group
• Subjects: 692/499; 692/699/1585; 692/700/2814; Accumulation; Adhesion; Adult; Advanced glycation end products; Advanced glycosylation end products; Age; Aged; Blood; Body Mass Index; Body size; C-reactive protein; Cell adhesion; Clinical Nutrition; Energy Intake; Epidemiology; Fatty acid-binding protein; Fatty acids; Female; Fluorescence; Glycation End Products, Advanced - administration & dosage; Glycation End Products, Advanced - adverse effects; Glycation End Products, Advanced - blood; Glycosylation; Hemodialysis; Hemodialysis patients; Humans; Intakes; Internal Medicine; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Male; Measurement; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Mortality; Nutrition; Obesity - complications; original-article; Oxidative stress; Patient outcomes; Peroxidase; Peroxidase - blood; Physiological aspects; Proteins; Public Health; Renal Dialysis; Skin; Superoxide dismutase; Von Willebrand factor
• ISSN: 0954-3007; 1476-5640; 1476-5640
• DOI: 10.1038/ejcn.2014.261

Background/Objectives: The level of skin autofluorescence (AF) at a given moment is an independent predictor of mortality in hemodialysis (HD) patients. Skin AF is a measure of the accumulation of advanced glycation end products (AGEs). The aim of the study was to estimate the influence of nutrition on the 1-year increase of skin AF (ΔAF) in HD patients. Subjects/Methods: A total of 156 HD patients were enrolled in this study. Skin AF, body mass index (BMI), superoxide dismutase, myeloperoxidase, C-reactive protein, inter-cellular adhesion molecule-1, von Willebrand factor and heart-type fatty acid-binding protein were measured four times at intervals of approximately half a year. Data from the monthly routine blood analysis were also used. Daily calorie, protein and AGE intakes were assessed from food recordings over a period of 1 week. Results: A J-shaped relation was found between baseline BMI and ΔAF ( P =0.01). The lowest point of the J-shaped curve is found for BMI=24.3 kg/m 2 . In the univariate analysis of the contributors to the 1-year ΔAF, we found that beside BMI=24.3 kg/m 2 , AGE and calorie intakes, as well as myeloperoxidase and HD vintage, had a P <0.10. The sole independent predictor of the 1-year ΔAF was BMI=24.3 kg/m 2 ( P =0.01). Conclusions: It appears that calorie, protein and AGE intakes hardly influence the 1-year ΔAF in HD patients. BMI of HD patients of around 24 kg/m 2 resulted in a lower 1-year ΔAF.