Resveratrol Ameliorates the Oxidative Damage Induced by Arsenic Trioxide in the Feline Lung

• Published in: Journal of Veterinary Medical Science Vol. 75; no. 9; pp. 1139 - 1146
• Main Authors: CHENG, Yanyan, XUE, Jiangdong, YAO, Chunyu, GAO, Li, MA, Dexing, LIU, Yan, ZHANG, Zhigang
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2013; Japan Science and Technology Agency
• Subjects: Analysis of Variance; Animals; Arsenic Trioxide; Arsenicals; Cat Diseases - chemically induced; Cat Diseases - drug therapy; Cats; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Female; Gene Expression Regulation, Enzymologic - drug effects; lung; Lung Diseases - chemically induced; Lung Diseases - drug therapy; Lung Diseases - veterinary; Male; oxidative damage; Oxidative Stress - drug effects; Oxides - toxicity; Reactive Oxygen Species - metabolism; Resveratrol; Stilbenes - pharmacology; Stilbenes - therapeutic use
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.13-0004

The objective of this study was to evaluate the possible protection of resveratrol against lung injury induced by arsenic trioxide (As2O3). Twenty-four healthy Chinese Dragon Li cats of either sex were randomly divided into four groups: control (1 ml/kg physiological saline), As2O3 (1 mg/kg), resveratrol (3 mg/kg) and resveratrol (3 mg/kg) + As2O3 (1 mg/kg). The resveratrol + As2O3- treated group was given resveratrol 1 hr before As2O3 (1 mg/kg) administration. We found that pretreatment with resveratrol in a clinically comparable dose regimen can reversed the changes in morphological and biochemical parameters induced by As2O3 in the lung. Resveratrol treatment also upregulated the activities of antioxidant enzymes and attenuated As2O3-induced increases in reactive oxygen species, 8-hydroxydeoxyguanosine and malondialdehyde production in the lung. In addition, resveratrol attenuated the As2O3-induced reduction in the ratio of reduced glutathione to oxidized glutathione, the content of total glutathione and lung arsenic burden. These findings indicated that resveratrol can provide significant protection against As2O3-induced oxidative damage.