Effect of Administration of Lactobacillus gasseri on Serum Lipids and Fecal Steroids in Hypercholesterolemic Rats

• Published in: Journal of dairy science Vol. 83; no. 8; pp. 1705 - 1711
• Main Authors: Usman, Hosono, A.
• Format: Journal Article
• Language: English
• Published: Savoy, IL Elsevier Inc 01.08.2000; Am Dairy Sci Assoc; American Dairy Science Association
• Subjects: Animals; Biological and medical sciences; Cholesterol - blood; Cholesterol, Dietary - administration & dosage; Colony Count, Microbial; Disorders of blood lipids. Hyperlipoproteinemia; fecal steroids; Feces - chemistry; Feces - microbiology; Fermentation; Hypercholesterolemia - metabolism; Lactobacillus - growth & development; Lactobacillus gasseri; Lipids - blood; Male; Medical sciences; Metabolic diseases; Milk - physiology; Probiotics; Rats; Rats, Wistar; serum lipids; Steroids - analysis; HDL; SKM; LDL; NFM-A; NFM-B; fecal steroids; serum lipids; Lactobacillus gasseri; Probiotic; Lactic acid bacteria; Excretion; Nutrition; Rat; Animal feeding; Rodentia; Metabolic diseases; Lipids; Microflora; Supplemented diet; Metabolism; Cholesterol; Vertebrata; Mammalia; Hypercholesterolemia; Animal; Bacteria; Lactobacillaceae; Feces; Milk
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.S0022-0302(00)75039-9

The effects of milk and nonfermented milks produced from Lactobacillus gasseri on serum lipids and total bile acids and fecal steroids and microflora were estimated in rats fed cholesterol-enriched diets. Lactobacilli decreased and coliforms increased in feces of the control group; however, the concentrations of fecal lactobacilli remained unchanged when rats were fed non-fermented milks. Fecal coliforms in rats receiving milk and nonfermented milk produced from L. gasseri SBT0270 increased, while rats receiving nonfermented milk produced from L. gasseri SBT0274 had lower fecal coliform count than did the control group. Only NFM-A significantly reduced serum total cholesterol and low-density lipoprotein (LDL) cholesterol, and bile acids. High-density lipoprotein (HDL) cholesterol was significantly decreased when rats were given milk and nonfermented milks. Milk and NFM-A lowered serum triglycerides levels. Milk and nonfermented milks did not affect the total neutral steroids, but higher levels of acidic steroid were detected in the feces than the control group. The results showed that the hypocholesterolemic effect of L. gasseri SBT0270 was attributed to its ability to suppress the reabsorption of bile acids into the enterohepatic circulation and to enhance the excretion of acidic steroids in feces of hypercholesterolemic rats.