Comparison of glaucomatous from non-glaucomatous optic neuropathy using Bruch's membrane opening minimum rim width optical coherence tomography measurements

• Published in: Indian journal of ophthalmology Vol. 71; no. 8; pp. 3005 - 3009
• Main Authors: Gosalia, Hirika, Kumar, Karthik, Karan, A, Saravanan, Veerappan, Shah, Virna
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.08.2023; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Atrophy; Bruch Membrane; bruch's membrane opening; Comparative analysis; compressive optic neuropathy; CT imaging; Diagnosis; Eye; Glaucoma; Glaucoma - diagnosis; glaucomatous optic atrophy; Humans; Intraocular Pressure; Nerve Fibers; Optic atrophy; Optic Nerve Diseases - diagnosis; Optic neuropathy; optical coherence tomography; Optical tomography; Optics; Original; Patients; Regression analysis; Retinal Ganglion Cells; Tomography; Tomography, Optical Coherence - methods; Visual Fields; India; optic atrophy; glaucomatous optic atrophy; compressive optic neuropathy; optical coherence tomography; Bruch's membrane opening
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/IJO.IJO_3171_22

Purpose: To compare glaucomatous from non-glaucomatous optic atrophy using optical coherence tomography (OCT) based on the measurement values of Bruch's membrane opening minimum rim width (BMO-MRW), which is a difficult task otherwise due to their varied course of disease progression, treatment protocols, and systemic association to visual impairment. Methods: This study was conducted in 40 eyes, comprising 20 eyes with non-glaucomatous optic neuropathy (NGON) and 20 eyes with glaucomatous optic neuropathy (GON). All patients underwent a complete ophthalmic examination followed by an OCT optic disc scan to calculate the measurement of BMO-MRW. Results: The 5-fold cross-validated area under the curve for GON versus NGON from logistic regression models was 0.95 (95% confidence interval [CI]: 0.86-1.00) using BMO-MRW values from all sectors. The results revealed that the measurements were significantly lesser in GON than in NGON patients. Conclusion: Hence, OCT-based BMO-MRW values could be used as an additional test to compare glaucomatous with non-glaucomatous optic neuropathy patients, especially in cases of high clinical suspicion.