Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress
Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p4...
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Published in | FEBS open bio Vol. 2; no. 1; pp. 328 - 333 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier B.V
01.01.2012
John Wiley & Sons, Inc Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.
▸ Resolvin E1 plays a part in protecting macrophage function from damage by cigarette smoke. ▸ RvE1 blocks CSE-induced ROS production in a macrophage cell line, RAW264.7. ▸ RvE1 suppresses the translocation of p47phox to membranes induced by CSE. ▸ RvE1 attenuates the damage of phagocytosis function and cell death induced by CSE. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2211-5463 2211-5463 |
DOI: | 10.1016/j.fob.2012.10.001 |