Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications

• Published in: Leukemia Vol. 25; no. 7; pp. 1095 - 1102
• Main Authors: STAAL, Fjt, BAUM, C, MOORE, K, MORENO, E, MUMMERY, C. L, ROBIN, C, SUDA, T, VAN PEL, M, VANDEN BRINK, G, ZWAGINGA, J. J, FIBBE, W. E, COWAN, C, DZIERZAK, E, HACEIN-BEY-ABINA, S, KARLSSON, S, LAPIDOT, T, LEMISCHKA, I, MENDEZ-FERRER, S, MIKKERS, H
• Format: Journal Article
• Language: English
• Published: Avenel, NJ Nature Publishing Group 01.07.2011
• Subjects: Adult; Animals; Biological and medical sciences; Biology; Blood transfusions; Bone marrow; Bone Marrow Cells - cytology; Cancer and Oncology; Cancer och onkologi; Cell self-renewal; Clinical Medicine; Clinical Trials as Topic - methods; Disease; Disease Models, Animal; embryonic stem cell; Embryonic Stem Cells - cytology; Embryos; Gene therapy; Genetic disorders; Genetic Therapy - methods; Genetic Vectors - administration & dosage; Genetic Vectors - therapeutic use; Health aspects; Hematologic and hematopoietic diseases; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Humans; Induced Pluripotent Stem Cells - cytology; Intestine; Intestines - cytology; iPS; Klinisk medicin; Leukemia; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Medicine; Mice; Neoplastic Stem Cells - cytology; Organ Specificity; Patient Selection; Physiological aspects; Pluripotency; Regenerative Medicine - methods; Signal generation; stem cell; Stem Cell Transplantation - adverse effects; Stem Cell Transplantation - methods; Stem cells; Stem Cells - classification; Stem Cells - cytology; Therapy; Transcription factors; transplantation; Netherlands; United States > US; Hematology; Digestive system; Stem cell; Gut; Transplantation; iPS; Self renewal; Treatment; embryonic stem cell; Embryonic cell; Surgery; Bone marrow; Graft; Gene therapy
• ISSN: 0887-6924; 1476-5551; 1476-5551
• DOI: 10.1038/leu.2011.52

The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies.