Burning down the house: cellular actions during pyroptosis

• Published in: PLoS pathogens Vol. 9; no. 12; p. e1003793
• Main Authors: LaRock, Christopher N, Cookson, Brad T
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2013; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Apoptosis - immunology; Autophagy; Cell adhesion & migration; Cell death; Humans; Immune system; Immunity, Innate - physiology; Inflammation - immunology; Interleukin-18 - physiology; Interleukin-1beta - physiology; Kinases; Medical research; Medicine, Experimental; Pearls; Proteins; Salmonella; Secretory Pathway - immunology; United States; Animals; Humans; Secretory Pathway; Inflammation; Interleukin-1beta; Immunity, Innate; Interleukin-18; Apoptosis
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1003793

  (D) Intracellular pathogens and antimicrobial factors that kill extracellular bacteria can be released by lysosomal exocytosis, also promoting adaptive immune responses through cross-priming. Lysis of infected macrophages releases intracellular Salmonella for subsequent phagocytosis and killing by neutrophils [2]. [...]depriving a replicative niche to intracellular pathogens through pyroptosis is one critical contribution of caspase-1 during some infections. The robustness of this pathway is normally well-controlled by NLR stringency; however, "hair-trigger" activation of caspase-1 drives inflammation during atherosclerosis, diabetes, Alzheimer's, inflammatory bowel disease, cancer, and several auto-inflammatory genetic disorders. [...]implications for treatment of the diseases of both industrial and developing countries can come from further study of caspase-1 regulation and signaling.