Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS
[...]GWAS of clinical phenotypes can alert host-pathogen researchers to unexpected links between their pathway of study and human disease. [...]an SNP upstream of NOD2 protects against IBD but leads to increased risk of leprosy [4]. [...]there are phenotypic trade-offs in genetic variation that ma...
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Published in | PLoS pathogens Vol. 9; no. 8; p. e1003424 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
01.08.2013
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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Summary: |
[...]GWAS of clinical phenotypes can alert host-pathogen researchers to unexpected links between their pathway of study and human disease. [...]an SNP upstream of NOD2 protects against IBD but leads to increased risk of leprosy [4]. [...]there are phenotypic trade-offs in genetic variation that may only be revealed under certain environmental situations. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 The authors have declared that no competing interests exist. |
ISSN: | 1553-7374 1553-7366 1553-7374 |
DOI: | 10.1371/journal.ppat.1003424 |