Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS

  [...]GWAS of clinical phenotypes can alert host-pathogen researchers to unexpected links between their pathway of study and human disease. [...]an SNP upstream of NOD2 protects against IBD but leads to increased risk of leprosy [4]. [...]there are phenotypic trade-offs in genetic variation that ma...

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Bibliographic Details
Published inPLoS pathogens Vol. 9; no. 8; p. e1003424
Main Authors Ko, Dennis C, Urban, Thomas J
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.08.2013
Public Library of Science (PLoS)
Subjects
Biology
Communicable Diseases - genetics
Disease susceptibility
Genes
Genetic aspects
Genetic Predisposition to Disease
Genetic Variation
Genome-wide association studies
Genome-Wide Association Study
Host-parasite relationships
Humans
Infections
Mutation
Pearls
Studies
United States
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Summary:  [...]GWAS of clinical phenotypes can alert host-pathogen researchers to unexpected links between their pathway of study and human disease. [...]an SNP upstream of NOD2 protects against IBD but leads to increased risk of leprosy [4]. [...]there are phenotypic trade-offs in genetic variation that may only be revealed under certain environmental situations.
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003424