Transfer of intestinal bacterial components to mammary secretions in the cow

• Published in: PeerJ (San Francisco, CA) Vol. 3; p. e888
• Main Authors: Young, Wayne, Hine, Brad C, Wallace, Olivia A M, Callaghan, Megan, Bibiloni, Rodrigo
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 23.04.2015; PeerJ, Inc; PeerJ Inc
• Subjects: Allergic diseases; Animals; Antigens; Asthma; Bacteria; Bifidobacterium; Biotechnology; Breast milk; Cattle; Childhood asthma; Children; Cow milk; Cow's milk; Dendritic cells; Epidemiology; Feces; Genetics; High-throughput sequencing; Hypersensitivity; Immune system; Immunology; Intestine; Lactation; Mammary gland; Medical research; Microbiology; Microbiota (Symbiotic organisms); Milk; Pediatrics; Rural areas; Secretions; White blood cells; White blood cells; Cow milk; Bifidobacterium; Feces; Mammary gland; High-throughput sequencing
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.888

Results from large multicentre epidemiological studies suggest an association between the consumption of raw milk and a reduced incidence of allergy and asthma in children. Although the underlying mechanisms for this association are yet to be confirmed, researchers have investigated whether bacteria or bacterial components that naturally occur in cow's milk are responsible for modulating the immune system to reduce the risk of allergic diseases. Previous research in human and mice suggests that bacterial components derived from the maternal intestine are transported to breast milk through the bloodstream. The aim of our study was to assess whether a similar mechanism of bacterial trafficking could occur in the cow. Through the application of culture-independent methodology, we investigated the microbial composition and diversity of milk, blood and feces of healthy lactating cows. We found that a small number of bacterial OTUs belonging to the genera Ruminococcus and Bifidobacterium, and the Peptostreptococcaceae family were present in all three samples from the same individual animals. Although these results do not confirm the hypothesis that trafficking of intestinal bacteria into mammary secretions does occur in the cow, they support the existence of an endogenous entero-mammary pathway for some bacterial components during lactation in the cow. Further research is required to define the specific mechanisms by which gut bacteria are transported into the mammary gland of the cow, and the health implications of such bacteria being present in milk.