Chicken Interleukin-5 is Expressed in Splenic Lymphocytes and Affects Antigen-Specific Antibody Production

Vaccination is important for reducing disease incidence in the poultry industry. To enhance immunity and vaccine efficacy, chicken cytokines associated with antibody production must be identified. In this study, we focused on interleukin-5 (IL-5), involved in antibody production in mice, measuring i...

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Bibliographic Details
Published inThe Journal of Poultry Science Vol. 61; p. 2024002
Main Authors Watanabe, Tenkai, Terada, Takumi, Ezaki, Ryo, Matsuzaki, Mei, Furusawa, Syuichi, Horiuchi, Hiroyuki
Format Journal Article
LanguageEnglish
Published Japan Japan Poultry Science Association 01.01.2024
Subjects
antibody production
IgA production
interleukin-5
Reseacrh Note
splenic lymphocyte
antibody production
IgA production
splenic lymphocyte
interleukin-5
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Summary:Vaccination is important for reducing disease incidence in the poultry industry. To enhance immunity and vaccine efficacy, chicken cytokines associated with antibody production must be identified. In this study, we focused on interleukin-5 (IL-5), involved in antibody production in mice, measuring its expression and effects on antibody production. Concanavalin A-stimulated splenocytes were used for RT-PCR to clone IL5 cDNAs. Recombinant IL-5 was prepared from the clone and administered to chickens with antigen via the ocular-topical route twice every alternate week. IL-5 enhanced antigen-specific IgY and inhibited antigen-specific serum IgA production in serum. Our findings suggest that IL-5 plays an important role in chicken antibody production, with possible unique functions.
Bibliography:ObjectType-Article-1
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ISSN:1346-7395
1349-0486
DOI:10.2141/jpsa.2024002