Cardiotonic Activity of the Rhizome of Polygonatum sibiricum in Rats

• Published in: Biological & pharmaceutical bulletin Vol. 20; no. 12; pp. 1271 - 1273
• Main Authors: HIRAI, Nobuaki, MIURA, Toshihiro, MORIYASU, Masataka, ICHIMARU, Momoyo, NISHIYAMA, Yumi, OGURA, Kazue, KATO, Atsushi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.12.1997; Maruzen; Japan Science and Technology Agency
• Subjects: 3',5'-Cyclic-AMP Phosphodiesterases - metabolism; Adrenergic alpha-Antagonists - pharmacology; Animals; beta adrenoceptor; Biological and medical sciences; Cardiotonic Agents - isolation & purification; Cardiotonic Agents - pharmacology; cardiotonic effect; Cardiovascular Agents - pharmacology; General pharmacology; Male; Medical sciences; Myocardial Contraction - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phentolamine - pharmacology; Plant Extracts - pharmacology; Plant Roots - chemistry; Plants, Medicinal - chemistry; Polygonati Rhizoma; Rats; Rats, Sprague-Dawley; Reserpine - pharmacology; Sodium-Potassium-Exchanging ATPase - metabolism; Sympatholytics - pharmacology; Monocotyledones; Cardiotonic agent; Rat; Esterases; Extract; Phosphoric diester hydrolases; K; Left atrium; Medicinal plant; β-Adrenergic receptor; Hypoglycemic agent; Na; Enzymatic activity; Angiospermae; Rhizome; 3',5'-Cyclic-nucleotide phosphodiesterase; Enzyme; Pharmacognosy; Rodentia; Biological activity; Liliaceae; Vertebrata; Mammalia; Animal; Plant origin; Hydrolases; exchanging ATPase; Spermatophyta
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.20.1271

The cardiotonic effect of the rhizome of Polygonatum sibiricum was investigated in the left atria of rats. The methanol extract of the rhizome of Polygonatum sibiricum (OM) (1-7 mg/ml) concentration-dependently increased the developed tension of the left atrium. It also strongly inhibited cAMP phosphodiesterase. The increase cAMP level correlated the increase in left atrial contraction. On the other hand, OM did not inhibit Na+, K+-ATPase. The cardiotonic effect of OM was strongly inhibited by reserpine, a sympatholytic agent. Futhermore, OM-treated left atria inhibited the tension produced by propranolol, a beta adrenocepter antagonist. These findings suggested that the cardiotonic effect is due to stimulating beta adrenoceptors through activation of sympathetic nerves.