SIDEROCHELIN, A NEW FERROUS-ION CHELATING AGENT PRODUCED BY NOCARDIA

A new ferrous-ion chelating agent, siderochelin, was isolated from fermentation broths of Nocardia sp. SC 11, 340. Siderochelin was produced by conventional submerged culture and purified by solvent extraction and recrystallization. The antibiotic was crystallized from acetonitrile as a mixture of d...

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Published inJournal of antibiotics Vol. 34; no. 7; pp. 791 - 799
Main Authors Liu, WEN-CHIN, FISHER, SUSAN M., WELLS, J. Jr. SCOTT, RICCA, CAROLYN S., PRINCIPE, PACIFICO A., TREJO, WILLIAM H., BONNER, DANIEL P., GOUGOUTOS, JACK Z., TOEPLITZ, BARBARA K., SYKES, RICHARD B.
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1981
Subjects
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Chelating Agents - metabolism
Crystallography
Dihydropyridines
Nocardia
Nocardia - classification
Nocardia - metabolism
Pyridines - analysis
Pyridines - biosynthesis
Pyridines - pharmacology
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Summary:A new ferrous-ion chelating agent, siderochelin, was isolated from fermentation broths of Nocardia sp. SC 11, 340. Siderochelin was produced by conventional submerged culture and purified by solvent extraction and recrystallization. The antibiotic was crystallized from acetonitrile as a mixture of diastereoisomers. The molecular formula of siderochelin was determined as C11H13N303 on the basis of elemental analysis and mass spectrometry, and the structure was elucidated by X-ray crystallography. The compound shows a broad spectrum of antimicrobial activity, being active against bacteria, fungi and protozoa.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.791