Both subscales of the Keratoconus End-Points Assessment Questionnaire have excellent test-retest reliability

• Published in: Indian journal of ophthalmology Vol. 69; no. 9; pp. 2430 - 2435
• Main Authors: Balparda, Kepa, Galarreta, David, Vanegas-Ramirez, Claudia, Silva-Quintero, Laura, Botero-Giraldo, Mariana, Maya-Naranjo, Maria, Pizarro-Marín, Paula
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01.09.2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Confidence intervals; cornea; Evaluation; eyes; Health surveys; Keratoconus; ophthalmology; Patients; Quality of life; Questionnaires; Special Focus, Ocular Surface and Cornea, Original; Surveys; vision; Colombia; United States > US; vision; Cornea; ophthalmology; keratoconus; eyes
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/ijo.IJO_3569_20

Purpose: The keratoconus end-points assessment questionnaire (KEPAQ) is a disease-specific scale designed to evaluate the quality of life in keratoconus patients and provides the measurement of both functional and emotional compromise in keratoconus. It was previously developed, tested, and validated and now we want to evaluate the test-retest reliability of the KEPAQ, in an effort to contribute evidence on its internal consistency and capability of measuring clinical state with minimal inference of random chance. Methods: This is a prospective analytical study, designed to evaluate the test-retest reliability of the KEPAQ through the repeated application of the questionnaire to a group of clinically stable individuals. A number of patients with a confirmed diagnosis of keratoconus underwent double application of the KEPAQ, seven days apart. Mean KEPAQ score was obtained through Rasch analysis, while test-retest reliability was evaluated through Spearman rank-order correlation and intraclass correlation coefficient. Rasch analysis was performed in JMetrik version 4.1.1 (Psychomeasurement Systems LLC; Charlottesville, VA, USA) in a MacBook Air computer running macOS Catalina version 10.15.2 (Apple Inc.; Cupertino, CA, USA). Results: A total of 100 patients were included. For KEPAQ-E, Spearman correlation was R = 0.963 while ICC was 0.981 (95% confidence interval 0.972-0.987). For KEPAQ-F, Spearman correlation was R = 0.921 while ICC was 0.952 (95% confidence interval 0.929-0.968). Conclusion: The KEPAQ is a robust, well-developed, extremely reliable scale which can be confidently used for clinical and research endeavors.