新型促排剂WSC-DTPA纳米粒对内污染铀的促排和防护作用

研究水溶性低分子壳聚糖-二乙烯三氨五乙酸（WSC-DTPA）纳米粒对内污染铀的促排效果和防护作用。对大鼠采用腹腔注射硝酸铀酰（0．5mgU·kg^-1）染毒，即刻分别尾静脉注射92．7％WSC—DTPA纳米粒、1．59％WSC—DTPA纳米粒和WSC纳米粒和DTPA—CaNa3，给药剂量均为60mg·kg^-1，ICP测量第1d、2d、3d的尿和粪中铀的排出量，以及给药3d后肝、脾、肾和骨中铀蓄积量；相同方式的染毒（2．0mgU·kg^-1）和处理，测量给药5d后肝、脾、肾和骨中铀蓄积量，并通过肝、肾、脾的病理切片和骨髓细胞涂片，观察损伤程度。结果显示：92．7％WSC-DTPA纳米粒、1．5...

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Bibliographic Details
Published in辐射研究与辐射工艺学报 Vol. 31; no. 4; pp. 13 - 18
Main Author 胡丹飞 毕梦 袁海浪 张友九
Format Journal Article
LanguageChinese
Published 苏州大学卫生与环境技术研究所 苏州215123 2013
苏州大学医学部放射医学与防护学院江苏省放射医学与防护重点实验室 苏州215123%苏州大学卫生与环境技术研究所 苏州215123%苏州大学医学部放射医学与防护学院江苏省放射医学与防护重点实验室 苏州215123
Subjects
WSC-DTPA纳米粒
促排
辐射防护
铀
铀
Uranium
WSC-DTPA nanoparticles
Decorporation
促排
辐射防护
Radiation protection
WSC-DTPA纳米粒
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ISSN1000-3436

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Summary:研究水溶性低分子壳聚糖-二乙烯三氨五乙酸（WSC-DTPA）纳米粒对内污染铀的促排效果和防护作用。对大鼠采用腹腔注射硝酸铀酰（0．5mgU·kg^-1）染毒，即刻分别尾静脉注射92．7％WSC—DTPA纳米粒、1．59％WSC—DTPA纳米粒和WSC纳米粒和DTPA—CaNa3，给药剂量均为60mg·kg^-1，ICP测量第1d、2d、3d的尿和粪中铀的排出量，以及给药3d后肝、脾、肾和骨中铀蓄积量；相同方式的染毒（2．0mgU·kg^-1）和处理，测量给药5d后肝、脾、肾和骨中铀蓄积量，并通过肝、肾、脾的病理切片和骨髓细胞涂片，观察损伤程度。结果显示：92．7％WSC-DTPA纳米粒、1．59％WSC—DTPA纳米粒和DTPA-CaNa3有较好的促排效果，且1．59％WSC-DTPA纳米粒促排效果明显优于DTPA-CaNa3组，有显著性差异（p〈0．05）；0．5mgU·kg^-1染毒给药组的组织蓄积量明显低于对照组；组织切片显示：92．7％WSC-DTPA纳米组对2．0mgU·kg^-1染毒大鼠的肝、肾有保护作用。结果表明：92．7％WSC-DTPA纳米粒不仅有促排作用，而且对铀染毒的大鼠的肝、肾组织有辐射防护作用。
Bibliography:Uranium, WSC-DTPA nanoparticles, Decorporation, Radiation protection
HU Danfei BI Meng1 YUAN Hailang2 ZHANG Youjiu1＇2 1（School of Radiation Medicine and Protection, Medical College of Soochow University, Jiangsu Province Key Laboratory of Radiation Medicine and Protection, Suzhou 215123, China） 2（Sanitation and Environment Technology Institute, Soochow University, Suzhou 215123, China）
31-1258/TL
To investigate the decorporation and radiation protection effects of WSC-DTPA nanoparticles on internal uranium exposure, the methods as followed were used. After SD rats were exposed to 0.5 mgU·kg^-1 uranyl nitrate by intraperitoneal injection, 92.7% WSC-DTPA nanoparticles, 1.59% WSC-DTPA nanoparticles, WSC nanoparticles and DTPA-CaNa3 were administered at 60 mg·kg^-1 dose through tail vein immediately. The contents of uranium in urine and feces at 1st, 2nd and 3rdday were measured by ICP, as well as those in liver, spleen, kidney and bone after 3 days. Exposed to 2.0 mgU·kg^-1 uranyl nitrate for 5 days, the contents o
ISSN:1000-3436