839-P: Peripheral and Central Blood Pressure Regulation in Recently Diagnosed Prediabetes

• Published in: Diabetes (New York, N.Y.) Vol. 69; no. Supplement_1
• Main Authors: BOGACZEWICZ-SLOWIKOWSKA, ANNA, ABRAMCZYK, PIOTR, CIENSZKOWSKA, KATARZYNA, JANECZKO-SOSNOWSKA, EWA, GACIONG, ZBIGNIEW, CZUPRYNIAK, LESZEK
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2020
• Subjects: Adiponectin; Blood pressure; Diabetes mellitus (non-insulin dependent); Insulin; Interleukin 8; Medical diagnosis
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db20-839-P

Hypertension is found in up to 90% people with type 2 diabetes. The relationship between blood pressure (BP) (dys)regulation and prediabetes is much less clear. Fifty individuals (mean age [±SD] 42.7±13.1 years, BMI 29.2±7.3 kg/m2) with prediabetes (31 IFG; 19 IGT) and normal BP and 20 age- and BMI-matched healthy persons (40.8±9.6 years, BMI 27.9±6.6 kg/m2) were enrolled into the study. In all participants fasting plasma insulin, adiponectin and interleukin-8 (IL-8) were assessed; and 24-hour ambulatory BP monitoring (ABPM Monitor Schiller BR-102 Plus) and central BP assessment with the applanation tonometry method (SphygmoCor XCEL) were perfomed. ABPM results were similar in both groups: 24-hour systolic, diastolic, mean arterial pressure (MAP) and pulse pressure were 124.1±10.8 and 123.5±7.6; 74.3±7.9 and 74.3±7.0; 89.8±7.2 and 90.4±6.6; 50.5±7.9 i 48.6±5.3 mmHg, respectively (p>0.05). In daytime the respective values were 127.0±11.2 and 126.6±7.4; 75.7±6.5 and 77.2±7.0; 92.4±7.5 and 93.2±6.5; 50.9±8.0 and 48.9±5.5 mmHg, and at nighttime 109.1±21.8 and 109.8±10.5; 61.5±12.7 and 62.7±8.8; 77.1±15.4 and 78.1±9.0; 47.1±11.3 and 46.7±5.4 mmHg (p>0.05). Central systolic, diastolic, end systolic BP, central mean pressure, central pulse height, augmentation index and central stroke volume index were also similar in both groups: 109.3±13.7 and 112.1±14.4, 77.1±9.5 and 80.4±10.7, 99.0±11.7 and 102.1±13.0, 91.3±10.6 and 95.2±11.4, 32.1±9.7 and 31.9±9.4 mmHg, 16.7±13.2 and 15.5±14.3%, 149.5±25.3 and 144.2±29.2 (p>0.05). No significant diffferences in plasma insulin, adiponectin or IL-8 were found between the groups (30.4±25.3 and 26.5±28.8 µIU/ml; 4.86±2.56 and 6.28±3.48 µg/ml; and 25.6±2.58 and 27.9±9.76 pg/ml, respectively, p>0.05). In conclusion, recently diagnosed prediabetes is not associated with any blood pressure abnormalities. Vigorous prevention of diabetes in people with prediabetes should be encouraged as it may lead to maintaining cardiovascular health. Disclosure A. Bogaczewicz-Slowikowska: None. P. Abramczyk: None. K. Cienszkowska: None. E. Janeczko-Sosnowska: None. Z. Gaciong: None. L. Czupryniak: None.