Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
Philippe Froguel and colleauges present a genome-wide association study for early-onset and morbid adult obesity, reporting three new genetic associations to obesity. We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-...
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| Published in | Nature genetics Vol. 41; no. 2; pp. 157 - 159 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.02.2009
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Philippe Froguel and colleauges present a genome-wide association study for early-onset and morbid adult obesity, reporting three new genetic associations to obesity.
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to
FTO
and
MC4R
, we detected significant association of obesity with three new risk loci in
NPC1
(endosomal/lysosomal Niemann-Pick C1 gene,
P
= 2.9 × 10
−7
), near
MAF
(encoding the transcription factor c-MAF,
P
= 3.8 × 10
−13
) and near
PTER
(phosphotriesterase-related gene,
P
= 2.1 × 10
−7
). |
|---|---|
| AbstractList | We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)). We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 × 10^sup -7^), near MAF (encoding the transcription factor c-MAF, P = 3.8 × 10^sup -13^) and near PTER (phosphotriesterase-related gene, P = 2.1 × 10^sup -7^). [PUBLICATION ABSTRACT] We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)). We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x [10.sup.-7]), near MAF (encoding the transcription factor c-MAF, P = 3.8 x [10.sup.-13]) and near PTER (phosphotriesterase-related gene, P = 2.1 x [10.sup.-7]). Philippe Froguel and colleauges present a genome-wide association study for early-onset and morbid adult obesity, reporting three new genetic associations to obesity. We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R , we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 × 10 −7 ), near MAF (encoding the transcription factor c-MAF, P = 3.8 × 10 −13 ) and near PTER (phosphotriesterase-related gene, P = 2.1 × 10 −7 ). We analyzed genome-wide association data from 1,380 Europeans with early- onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 [math] 10 super(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 [math] 10 super(- 13)) and near PTER (phosphotriesterase-related gene, P = 2.1 [math] 10 super(-7)). |
| Audience | Academic |
| Author | Balding, David Montpetit, Alexandre Sladek, Rob Chèvre, Jean-Claude Heude, Barbara Gaget, Stefan Polychronakos, Constantin Horber, Fritz McCarthy, Mark I Visvikis-Siest, Sophie Tichet, Jean Coin, Lachlan J M Lecoeur, Cécile Blakemore, Alexandra I F Proença, Christine Kiess, Wieland Asher, Julian Tauber, Maithé Balkau, Beverley Körner, Antje Meyre, David Elliott, Paul Järvelin, Marjo-Riitta Weill, Jacques Vatin, Vincent Hercberg, Serge Potoczna, Natascha Delplanque, Jérôme Gallina, Sophie Kovacs, Peter Hartikainen, Anna-Liisa Marre, Michel Dina, Christian Lobbens, Stéphane Durand, Emmanuelle Walley, Andrew Levy-Marchal, Claire Pattou, François Froguel, Philippe Degraeve, Franck |
| Author_xml | – sequence: 1 givenname: David surname: Meyre fullname: Meyre, David organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 2 givenname: Jérôme surname: Delplanque fullname: Delplanque, Jérôme organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 3 givenname: Jean-Claude surname: Chèvre fullname: Chèvre, Jean-Claude organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 4 givenname: Cécile surname: Lecoeur fullname: Lecoeur, Cécile organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 5 givenname: Stéphane surname: Lobbens fullname: Lobbens, Stéphane organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 6 givenname: Sophie surname: Gallina fullname: Gallina, Sophie organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 7 givenname: Emmanuelle surname: Durand fullname: Durand, Emmanuelle organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 8 givenname: Vincent surname: Vatin fullname: Vatin, Vincent organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 9 givenname: Franck surname: Degraeve fullname: Degraeve, Franck organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 10 givenname: Christine surname: Proença fullname: Proença, Christine organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 11 givenname: Stefan surname: Gaget fullname: Gaget, Stefan organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 12 givenname: Antje surname: Körner fullname: Körner, Antje organization: University Hospital for Children & Adolescents, University of Leipzig – sequence: 13 givenname: Peter surname: Kovacs fullname: Kovacs, Peter organization: Interdisciplinary Centre for Clinical Research, University of Leipzig – sequence: 14 givenname: Wieland surname: Kiess fullname: Kiess, Wieland organization: University Hospital for Children & Adolescents, University of Leipzig – sequence: 15 givenname: Jean surname: Tichet fullname: Tichet, Jean organization: Institut Inter Régional pour la Santé – sequence: 16 givenname: Michel surname: Marre fullname: Marre, Michel organization: Department of Endocrinology, Diabetology, Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hôpitaux de Paris, 75018 Paris, France, and Institut National de la Santé et de la Recherche Médicale U695, Université Paris 7 – sequence: 17 givenname: Anna-Liisa surname: Hartikainen fullname: Hartikainen, Anna-Liisa organization: Department of Clinical Sciences/ Obstetrics and Gynecology, University of Oulu, University of Oulu – sequence: 18 givenname: Fritz surname: Horber fullname: Horber, Fritz organization: Klinik Lindberg, 8400 Winterthur, and University of Berne – sequence: 19 givenname: Natascha surname: Potoczna fullname: Potoczna, Natascha organization: Klinik Lindberg, 8400 Winterthur, and University of Berne – sequence: 20 givenname: Serge surname: Hercberg fullname: Hercberg, Serge organization: Unité Mixte de Recherche U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Conservatoire National des arts et Métiers, Université Paris 13, Centre de Recherches en Nutrition Humaine Ile de France – sequence: 21 givenname: Claire surname: Levy-Marchal fullname: Levy-Marchal, Claire organization: Institut National de la Santé et de la Recherche Médicale, U690, Université Paris Diderot – sequence: 22 givenname: François surname: Pattou fullname: Pattou, François organization: Institut National de la Santé et de la Recherche Médicale U859, Centre Hospitalier Régional Universitaire de Lille, Lille North of France University – sequence: 23 givenname: Barbara surname: Heude fullname: Heude, Barbara organization: Institut National de la Santé et de la Recherche Médicale U780, Villejuif, F-94807; University Paris-Sud – sequence: 24 givenname: Maithé surname: Tauber fullname: Tauber, Maithé organization: Institut National de la Santé et de la Recherche Médicale U563, Children's Hospital, Centre Hospitalier Universitaire – sequence: 25 givenname: Mark I surname: McCarthy fullname: McCarthy, Mark I organization: Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford National Institute for Health Research Biomedical Research Centre – sequence: 26 givenname: Alexandra I F surname: Blakemore fullname: Blakemore, Alexandra I F organization: Section of Genomic Medicine, Hammersmith Hospital, Imperial College London – sequence: 27 givenname: Alexandre surname: Montpetit fullname: Montpetit, Alexandre organization: McGill University and Genome Quebec Innovation Centre – sequence: 28 givenname: Constantin surname: Polychronakos fullname: Polychronakos, Constantin organization: McGill University and Genome Quebec Innovation Centre – sequence: 29 givenname: Jacques surname: Weill fullname: Weill, Jacques organization: Pediatric Endocrine Unit, Jeanne de Flandre Hospital – sequence: 30 givenname: Lachlan J M surname: Coin fullname: Coin, Lachlan J M organization: Department of Epidemiology and Public Health, Imperial College London – sequence: 31 givenname: Julian surname: Asher fullname: Asher, Julian organization: Section of Genomic Medicine, Hammersmith Hospital, Imperial College London – sequence: 32 givenname: Paul surname: Elliott fullname: Elliott, Paul organization: Department of Epidemiology and Public Health, Imperial College London – sequence: 33 givenname: Marjo-Riitta surname: Järvelin fullname: Järvelin, Marjo-Riitta organization: Department of Epidemiology and Public Health, Imperial College London, Department of Child and Adolescent Health, Institute of Health Sciences, University of Oulu, National Public Health Institute, Biocenter Oulu, University of Oulu – sequence: 34 givenname: Sophie surname: Visvikis-Siest fullname: Visvikis-Siest, Sophie organization: Institut National de la Santé et de la Recherche Médicale “Cardiovascular Genetics” team, Centre D'investigation Clinique – sequence: 35 givenname: Beverley surname: Balkau fullname: Balkau, Beverley organization: Institut National de la Santé et de la Recherche Médicale U780, Villejuif, F-94807; University Paris-Sud – sequence: 36 givenname: Rob surname: Sladek fullname: Sladek, Rob organization: McGill University and Genome Quebec Innovation Centre – sequence: 37 givenname: David surname: Balding fullname: Balding, David organization: Department of Epidemiology and Public Health, Imperial College London – sequence: 38 givenname: Andrew surname: Walley fullname: Walley, Andrew organization: Section of Genomic Medicine, Hammersmith Hospital, Imperial College London – sequence: 39 givenname: Christian surname: Dina fullname: Dina, Christian organization: CNRS 8090-Institute of Biology, Pasteur Institute – sequence: 40 givenname: Philippe surname: Froguel fullname: Froguel, Philippe email: p.froguel@imperial.ac.uk organization: CNRS 8090-Institute of Biology, Pasteur Institute, Section of Genomic Medicine, Hammersmith Hospital, Imperial College London |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21236351$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19151714$$D View this record in MEDLINE/PubMed https://hal.science/hal-01655335$$DView record in HAL |
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| Snippet | Philippe Froguel and colleauges present a genome-wide association study for early-onset and morbid adult obesity, reporting three new genetic associations to... We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls.... We analyzed genome-wide association data from 1,380 Europeans with early- onset and morbid adult obesity and 1,416 age-matched normal-weight controls.... |
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| SubjectTerms | Adult Adults Age of Onset Agriculture Alpha-Ketoglutarate-Dependent Dioxygenase FTO Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Carrier Proteins - genetics Case-Control Studies Child Europe - epidemiology Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Gene loci Genetic aspects Genetic Predisposition to Disease Genetic testing Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Health aspects Human Genetics Humans Intracellular Signaling Peptides and Proteins Life Sciences Medical sciences Membrane Glycoproteins - genetics Metabolic diseases Niemann-Pick C1 Protein Obesity Obesity, Morbid - epidemiology Obesity, Morbid - genetics Polymorphism, Single Nucleotide Population Proteins - genetics Proto-Oncogene Proteins c-maf - genetics Quantitative Trait Loci Receptor, Melanocortin, Type 4 - genetics Risk Factors Single nucleotide polymorphisms |
| Title | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations |
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