Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

• Published in: Nature genetics Vol. 41; no. 2; pp. 157 - 159
• Main Authors: Meyre, David, Delplanque, Jérôme, Chèvre, Jean-Claude, Lecoeur, Cécile, Lobbens, Stéphane, Gallina, Sophie, Durand, Emmanuelle, Vatin, Vincent, Degraeve, Franck, Proença, Christine, Gaget, Stefan, Körner, Antje, Kovacs, Peter, Kiess, Wieland, Tichet, Jean, Marre, Michel, Hartikainen, Anna-Liisa, Horber, Fritz, Potoczna, Natascha, Hercberg, Serge, Levy-Marchal, Claire, Pattou, François, Heude, Barbara, Tauber, Maithé, McCarthy, Mark I, Blakemore, Alexandra I F, Montpetit, Alexandre, Polychronakos, Constantin, Weill, Jacques, Coin, Lachlan J M, Asher, Julian, Elliott, Paul, Järvelin, Marjo-Riitta, Visvikis-Siest, Sophie, Balkau, Beverley, Sladek, Rob, Balding, David, Walley, Andrew, Dina, Christian, Froguel, Philippe
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2009; Nature Publishing Group
• Subjects: Adult; Adults; Age of Onset; Agriculture; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; brief-communication; Cancer Research; Carrier Proteins - genetics; Case-Control Studies; Child; Europe - epidemiology; Fundamental and applied biological sciences. Psychology; Gene Frequency; Gene Function; Gene loci; Genetic aspects; Genetic Predisposition to Disease; Genetic testing; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Health aspects; Human Genetics; Humans; Intracellular Signaling Peptides and Proteins; Life Sciences; Medical sciences; Membrane Glycoproteins - genetics; Metabolic diseases; Niemann-Pick C1 Protein; Obesity; Obesity, Morbid - epidemiology; Obesity, Morbid - genetics; Polymorphism, Single Nucleotide; Population; Proteins - genetics; Proto-Oncogene Proteins c-maf - genetics; Quantitative Trait Loci; Receptor, Melanocortin, Type 4 - genetics; Risk Factors; Single nucleotide polymorphisms; Europe; Human; Obesity; Association; Nutrition disorder; Adult; Early; Risk; Identification; European; Locus; Nutritional status
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.301

Philippe Froguel and colleauges present a genome-wide association study for early-onset and morbid adult obesity, reporting three new genetic associations to obesity. We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R , we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 × 10 −7 ), near MAF (encoding the transcription factor c-MAF, P = 3.8 × 10 −13 ) and near PTER (phosphotriesterase-related gene, P = 2.1 × 10 −7 ).