Effect of Extracts of Zingiberaceae Herbs on Gastric Secretion in Rabbits
Some of the Zingiberaceae herbs are known to be useful as stomachics. Water extracts and methanol extracts of eight such herbs were examined in intact unanesthetized rabbits for their effect n gastric secretion. Oral administration of either water extratcs or methanol extracts caused a significant d...
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Published in | Chemical & pharmaceutical bulletin Vol. 37; no. 1; pp. 215 - 217 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
The Pharmaceutical Society of Japan
01.01.1989
Maruzen Japan Science and Technology Agency |
Subjects | |
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Abstract | Some of the Zingiberaceae herbs are known to be useful as stomachics. Water extracts and methanol extracts of eight such herbs were examined in intact unanesthetized rabbits for their effect n gastric secretion. Oral administration of either water extratcs or methanol extracts caused a significant decrease in gastric secretion. A significant effect of these extracts appeared at 3h after administration. The effect of water extracts on gastric secretion was very similar to that of cimetidine, with a significant decrease in acid output. The effect of the methanol extracts was primarily observed as decreased pepsin output. |
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AbstractList | Some of the Zingiberaceae herbs are known to be useful as stomachics. Water extracts and methanol extracts of eight such herbs were examined in intact unanesthetized rabbits for their effect on gastric secretion. Oral administration of either water extracts or methanol extracts caused a significant decrease in gastric secretion. A significant effect of these extracts appeared at 3 h after administration. The effect of water extracts on gastric secretion was very similar to that of cimetidine, with a significant decrease in acid output. The effect of the methanol extracts was primarily observed as decreased pepsin output. Some of the Zingiberaceae herbs are known to be useful as stomachics. Water extracts and methanol extracts of eight such herbs were examined in intact unanesthetized rabbits for their effect n gastric secretion. Oral administration of either water extratcs or methanol extracts caused a significant decrease in gastric secretion. A significant effect of these extracts appeared at 3h after administration. The effect of water extracts on gastric secretion was very similar to that of cimetidine, with a significant decrease in acid output. The effect of the methanol extracts was primarily observed as decreased pepsin output. |
Author | IKAWA, Chie SAITOH, Yukiko NISHIHATA, Toshiaki MIYAZAKI, Yohko SAKAI, Kiyoshi YAMANE, Toshiko |
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Copyright | The Pharmaceutical Society of Japan 1991 INIST-CNRS Copyright Japan Science and Technology Agency 1989 |
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References | 2) M. Kijima, S. Shibata, T. Shimomura and F. Higashi, "Yakuyo Shokubutsu Daijiten," Hirokawa, Tokyo, 1967, pp. 43, 48. 6) K. Watanabe, H. Watanabe and Y. Goto, Abstracts of 9th Wakanyaku Symposium, Toyama, Aug. 1975, p. 51. 5) S. Okabe, T. Takeuchi, H. Ikeda, F. Ohmi and A. Takaoka, Jpn. J. Pharmacol., 81, 285 (1983). 10) H. Ueda, S. Takeuchi and H. Kamata, "Rinshokensaho," 5th ed Kyorinshoin, Tokyo, 1964, p. 123. 13) Y.M. Takagaki and K. Hotta, Biochim. Biophys. Acta, 585, 288 (1979). 12) S. E. Williams and L. A. Turnberg, Gastroenterology, 79, 299 (1979). 11) S. Okabe, K. Takeuchi, T. Urushidani and K. Takagi, Am. J. Dig. Dis., 22, 677 (1979). 7) K. Sakai, Y. Fujihara, T. Nishino, T. Matsuura and A. Nishiura, Yakugaku Zasshi, 103, 319 (1983). 9) M.L. Anson, J. Gen. Physiol., 22, 79 (1938). 3) Kobechuigaku Kenkyukai, "Kanyaku No Rinsho-oyo," 1st ed Ishiyaku Shuppan, Tokyo, 1979, pp. 30, 197, 208, 210, 263, 275. 8) K. Sakai, M. Nakatani and M. Yamasaki, Yakugaku Zasshi, 101, 354 (1981). 1) K. Takagi, M. Kimura, M. Harada and K. Otsuka, "Wakan Yakubutsu Gaku," Nanzando, Tokyo, 1982, pp. 263, 267. 4) J. Watt, Gastroenterology, 37, 741 (1959). |
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SubjectTerms | Animals Biological and medical sciences Gastric Juice - metabolism Gastric Mucosa - drug effects Gastric Mucosa - metabolism General pharmacology Male Medical sciences oral administration Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal - analysis Rabbits |
Title | Effect of Extracts of Zingiberaceae Herbs on Gastric Secretion in Rabbits |
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