Studies on the Number of Contacts between Ibuprofen and Ethenzamide Using Thermal Analysis

• Published in: Chemical & pharmaceutical bulletin Vol. 48; no. 1; pp. 140 - 141
• Main Authors: AOKI, Shinji, MIZUTANI, Taku, DANJO, Kazumi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.01.2000; Maruzen; Japan Science and Technology Agency
• Subjects: Algorithms; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Biological and medical sciences; Calorimetry, Differential Scanning; Differential Thermal Analysis; ethenzamide; General pharmacology; ibuprofen; Ibuprofen - chemistry; Indicators and Reagents; Medical sciences; number of contact; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Salicylamides - chemistry; thermal analysis; Differential scanning calorimetry; Contact interaction; Non steroidal antiinflammatory agent; Analgesic; Ethenzamide; Ibuprofen; Antipyretic; Dosage form; Arylpropionic acid derivatives; Benzamide derivatives; Solid form; Drug interaction; Thermal analysis; Granule
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.48.140

We studied a method of estimating the number of contacts in a solid dosage form using thermal analysis. Ibuprofen (IB) and Ethenzamide (ET) were used as model actives. IB and ET were granulated and sieved with each other. We prepared mixtures of IB and ET using different diameter granules. The number of contacts between the samples was calculated by the expression method of Ouchiyama and Tanaka. By thermal analysis, we measured the quantity of endotherm up to 60-63°C from 56°C. The quantity of endotherm up to 61°C from 56°C was in good proportion to the number of contacts calculated by the expression.