上皮-间质转化在肿瘤发生发展中的作用研究进展

上皮—间质转化（ EMT ）是上皮细胞失去其形态和功能逐渐转化为间质样细胞的过程，与肿瘤复发和转移相关。 EMT的调控因素有很多，如E-钙黏蛋白、转化生长因子β、Wnt信号通路、微RNA及转录因子等。本文就目前关于EMT在肿瘤中的作用以及EMT的调节机制的研究进展做一综述，以期对肿瘤的治疗提供新的线索。...

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Bibliographic Details
Published in浙江大学学报（医学版） no. 2; pp. 211 - 216
Main Author 刘志娴 魏尔清 卢韵碧
Format Journal Article
LanguageChinese
Published 浙江大学医学院药理学系,浙江杭州,310058 2015
Subjects
上皮细胞/病理学
生物转化
综述
肿瘤
转录因子
钙黏着糖蛋白类
间质细胞/病理学
Transcription factors
Epithelial cells/pathology
生物转化
上皮细胞/病理学
Review
Neoplasms
Stromal cells/pathology
间质细胞/病理学
肿瘤
Biotransformation
Cadherins
转录因子
综述
钙黏着糖蛋白类
Online AccessGet full text
ISSN1008-9292
DOI10.3785/j.issn.1008-9292.2015.03.015

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Summary:上皮—间质转化（ EMT ）是上皮细胞失去其形态和功能逐渐转化为间质样细胞的过程，与肿瘤复发和转移相关。 EMT的调控因素有很多，如E-钙黏蛋白、转化生长因子β、Wnt信号通路、微RNA及转录因子等。本文就目前关于EMT在肿瘤中的作用以及EMT的调节机制的研究进展做一综述，以期对肿瘤的治疗提供新的线索。
Bibliography:Neoplasms;Cadherins;Transcription factors;Stromal cells/pathology;Epithelial cells/pathology;Biotransformation;Review
33-1248/R
Epithelial-mesenchymal transition （ EMT ） is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis .Many factors are involved in the regulation of EMT , such as E-cadherin , transforming growth factor-β, Wnt signaling pathway , microRNA and EMT-related transcription factors .This article reviews the research progress on EMT and the involved mechanisms , and thus to provide a new perspective on cancer therapy in the future .
LIU Zhi-xian, WEI Er-qing, LU Yun-bi （ Department of Pharmacology, Zhefiang University, School of Medicine, Hangzhou 310058, China）
ISSN:1008-9292
DOI:10.3785/j.issn.1008-9292.2015.03.015