Association of 2184AG Polymorphism in the RAGE Gene with Diabetic Nephropathy in Chinese Patients with Type 2 Diabetes

• Published in: Journal of Diabetes Research Vol. 2015; no. 2015; pp. 1 - 6
• Main Authors: Liu, Jian-Ying, Xiao, Jun-Ren, Zhang, Wei, Liu, Ying, Xu, Ji-Xiong, Li, Jian, Cai, Wei, Zhu, Ling-Yan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Age; Aged; Alleles; Asian Continental Ancestry Group - genetics; Blood pressure; China; Cholesterol; Creatinine; Deoxyribonucleic acid; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetic nephropathies; Diabetic Nephropathies - genetics; Diabetic nephropathy; Diabetic retinopathy; DNA; Fasting; Female; Gene Frequency; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic research; Genotype; Genotype & phenotype; Glucose; Hemoglobin; Humans; Hypertension; Kidney diseases; Laboratories; Male; Middle Aged; Pathogenesis; Polymorphism; Polymorphism, Single Nucleotide; Receptor for Advanced Glycation End Products - genetics; Signal transduction; Type 2 diabetes; Variables; United States > US
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2015/310237

Objective. The interaction between advanced glycation end products and their cellular receptor (RAGE) has an important role in the pathogenesis of diabetic microvascular complications. The aim of this study was to investigate the relationship between the 2184A/G polymorphism in the RAGE gene and diabetic nephropathy in Chinese Han patients with type 2 diabetes mellitus. Methods. A total of 868 patients with type 2 diabetes mellitus (486 without and 382 with diabetic nephropathy) were enrolled in this study. The genotype and allele frequencies of the 2184A/G polymorphism were detected using the polymerase chain reaction-restriction fragment-length polymorphism method. Results. The G allele and AG + GG genotype frequencies in patients with diabetic nephropathy were significantly lower than those in patients without diabetic nephropathy (P=0.001 and P=0.005, resp.). After adjustments for possible confounders, multivariate logistic regression analyses showed that the 2184A/G polymorphism was independently associated with diabetic nephropathy (OR = 0.46, 95% CI: 0.22–0.92, P=0.028). Conclusions. Our study indicated that the 2184A/G polymorphism in the RAGE gene was significantly associated with diabetic nephropathy in Chinese Han patients with type 2 diabetes.