Urticaria and basophils

Chronic spontaneous urticaria (CSU) is a common skin disease without an etiology in the vast majority of cases. The similarity of symptoms and pathology to allergen-induced skin reactions supports that skin mast cell IgE receptor activation is also involved in CSU. Accumulating evidence also support...

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Bibliographic Details
Published inAllergology international Vol. 72; no. 3; pp. 369 - 374
Main Author Saini, Sarbjit S.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.07.2023
Elsevier
Subjects
Basophils
Basophils - metabolism
Chronic Disease
Chronic Urticaria
FceRI
Hives
Humans
IgE
Receptors, IgE - metabolism
Urticaria
Hives
Basophils
Urticaria
IgE
FceRI
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Summary:Chronic spontaneous urticaria (CSU) is a common skin disease without an etiology in the vast majority of cases. The similarity of symptoms and pathology to allergen-induced skin reactions supports that skin mast cell IgE receptor activation is also involved in CSU. Accumulating evidence also supports a role for blood basophils in disease expression. Blood basopenia is noted in active CSU disease with the recruitment of blood basophils to skin lesion sites. Blood basophils further display altered IgE receptor mediated degranulation patterns in two phenotypes that improve in remission. In active CSU subjects, changes in IgE receptor signaling molecule expression levels accompany the altered degranulation function in blood basophils. The success of therapies targeting IgE in CSU patients have also shown that altered blood basophil phenotypes and enumeration have potential use as a disease biomarker.
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ISSN:1323-8930
1440-1592
1440-1592
DOI:10.1016/j.alit.2023.05.001