Evaluation of Cyclin D1 protein and its association with the clinicopathological characteristics and prognosis of lung cancer: A retrospective study from Southern Kerala, India
ABSTRACT Background: Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala. Aim: This study sought to evaluate...
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| Published in | Lung India Vol. 41; no. 6; pp. 429 - 434 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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India
Wolters Kluwer - Medknow
01.11.2024
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Edition | 2 |
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| ISSN | 0970-2113 0974-598X |
| DOI | 10.4103/lungindia.lungindia_257_24 |
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| Abstract | ABSTRACT
Background:
Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala.
Aim:
This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer.
Methods:
This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non-small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS.
Results:
The study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145).
Conclusion:
Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. |
|---|---|
| AbstractList | Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala. This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer. This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18), lung squamous cell carcinoma (27.9), non-small-cell lung carcinoma (18), poorly differentiated carcinoma (19.7), and negative for malignant cells (16.4). Data analysis was conducted using SPSS. The study revealed that 31.10 of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145). Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. ABSTRACT Background: Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala. Aim: This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer. Methods: This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18), lung squamous cell carcinoma (27.9), non-small-cell lung carcinoma (18), poorly differentiated carcinoma (19.7), and negative for malignant cells (16.4). Data analysis was conducted using SPSS. Results: The study revealed that 31.10 of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145). Conclusion: Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. Keywords: Cyclin D1, immunohistochemistry, lung cancer, prognosis Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala.BACKGROUNDCyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala.This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer.AIMThis study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer.This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non-small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS.METHODSThis retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non-small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS.The study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145).RESULTSThe study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145).Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis.CONCLUSIONCyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. ABSTRACTBackground:Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala.Aim:This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer.Methods:This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non-small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS.Results:The study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145).Conclusion:Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala. This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer. This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non-small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS. The study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145). Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. ABSTRACT Background: Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala. Aim: This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer. Methods: This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non-small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS. Results: The study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145). Conclusion: Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. Background Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala. Aim This study sought to evaluate the links between cyclin D1 expression, clinicopathological characteristics, and 2-year survival rates in lung cancer. Methods This retrospective cohort study used medical records and paraffin blocks of lung cancer patients at the Regional Cancer Centre in Kerala, India, between 2015 and 2018. The data were collected from 61 subjects, comprising of lung adenocarcinoma (18%), lung squamous cell carcinoma (27.9%), non–small-cell lung carcinoma (18%), poorly differentiated carcinoma (19.7%), and negative for malignant cells (16.4%). Data analysis was conducted using SPSS. Results The study revealed that 31.10% of the lung cancer patients exhibited overexpression of cyclin D1. A significant correlation was observed between cyclin D1 expression and histopathological results (P = 0.002), indicating that the level of cyclin D1 might be linked to specific histopathological subtypes of lung cancer. Despite this significant finding, cyclin D1 expression did not show any association with the clinical stage of the cancer or other clinical characteristics of the patients. Furthermore, when examining the 2-year survival rates of the patients, the study found no significant difference between those who had overexpression of cyclin D1 and those who did not (P = 0.145). Conclusion Cyclin D1 expression was associated with histology type of lung cancer with no significant association to prognosis. |
| Audience | Academic |
| Author | Lekshmi, Asha Nair, Jagathnath K. K. M. Sujathan, Kunjuraman Panakkal, Neeraja |
| AuthorAffiliation | 2 PhD Scholar, Manipal Academy of Higher Education (MAHE), Karnataka, India 1 Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India 3 Division of Epidemiology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India |
| AuthorAffiliation_xml | – name: 2 PhD Scholar, Manipal Academy of Higher Education (MAHE), Karnataka, India – name: 1 Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India – name: 3 Division of Epidemiology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India |
| Author_xml | – sequence: 1 givenname: Neeraja surname: Panakkal fullname: Panakkal, Neeraja – sequence: 2 givenname: Asha surname: Lekshmi fullname: Lekshmi, Asha – sequence: 3 givenname: Jagathnath K. K. M. surname: Nair fullname: Nair, Jagathnath K. K. M. – sequence: 4 givenname: Kunjuraman surname: Sujathan fullname: Sujathan, Kunjuraman email: ksujathan@gmail.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39465922$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.18632/oncotarget.26428 10.29245/2578-3009/2018/3.1142 10.1016/j.cllc.2011.10.003 10.1002/ijc.31937 10.1080/15384101.2019.1706903 10.1016/j.lungcan.2006.09.024 10.21037/tlcr.2019.12.01 10.1210/en.2004-0959 10.3322/caac.21660 10.1038/sj.bjc.6690661 10.3390/cells9122648 10.1038/onc.2015.296 10.1007/s13277-015-3620-y 10.1016/S0025-6196(11)60735-0 10.1016/S0022-5223(99)70121-2 10.1158/1940-6207.CAPR-11-0143 10.1002/(SICI)1096-9896(199908)188:4<351::AID-PATH385>3.0.CO;2-W 10.1056/NEJMsa1211127 10.1016/S0169-5002(00)00160-4 10.1007/s00405-014-3426-3 10.1128/MCB.23.13.4713-4727.2003 10.1016/j.chest.2016.10.010 |
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| Keywords | lung cancer immunohistochemistry Cyclin D1 prognosis |
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Background:
Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung... Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However,... ABSTRACT Background: Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung... ABSTRACTBackground:Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung... Background Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer.... |
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| SubjectTerms | Cyclin D proteins cyclin d1 Development and progression Health aspects immunohistochemistry Lung cancer Medical prognosis Medical research Medicine, Experimental Original Original Article Physiological aspects Prognosis Squamous cell carcinoma |
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| Title | Evaluation of Cyclin D1 protein and its association with the clinicopathological characteristics and prognosis of lung cancer: A retrospective study from Southern Kerala, India |
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