Seronegative autoimmune encephalitis - A diagnostic and therapeutic dilemma

[3] Diagnostic challenge occurs when there are no detectable auto-antibodies in serum or CSF; these subgroup of patients are termed Seronegative (or antibody-negative) autoimmune encephalitis (SAE) with suspected immunological origin based on clinical and imaging features. [...]a large proportion of...

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Bibliographic Details
Published inAnnals of the Indian Academy of Neurology Vol. 22; no. 4; pp. 369 - 370
Main Author Netravathi, M
Format Journal Article
LanguageEnglish
Published Mumbai Wolters Kluwer India Pvt. Ltd 01.10.2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
Antibodies
Antigens
Autoantibodies
Autoimmune diseases
Autoimmunity
Biomarkers
Care and treatment
Diagnosis
Encephalitis
Immunoglobulins
Immunotherapy
Seizures (Medicine)
India
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Summary:[3] Diagnostic challenge occurs when there are no detectable auto-antibodies in serum or CSF; these subgroup of patients are termed Seronegative (or antibody-negative) autoimmune encephalitis (SAE) with suspected immunological origin based on clinical and imaging features. [...]a large proportion of patients with suspected immune-mediated disorders do not have detectable auto-antibodies, resulting in diagnostic and therapeutic challenges. The field of autoimmune encephalitis is rapidly expanding with the advent of many newer auto-antibodies; the real life clinical experience of evaluation of AE without diagnostic biomarkers results in diagnostic and therapeutic challenges which has been addressed in this article.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0972-2327
1998-3549
DOI:10.4103/aian.AIAN_485_19