A systems approach to infectious disease

• Published in: Nature reviews. Genetics Vol. 21; no. 6; pp. 339 - 354
• Main Authors: Eckhardt, Manon, Hultquist, Judd F., Kaake, Robyn M., Hüttenhain, Ruth, Krogan, Nevan J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2020; Nature Publishing Group
• Subjects: 631/114/2114; 631/326/421; 631/553; 631/553/2711; 692/699/255; Agriculture; Animal Genetics and Genomics; Biology; Biomedical and Life Sciences; Biomedicine; Cancer Research; Communicable diseases; Communicable Diseases - therapy; Data Analysis; Data collection; Gene Function; Host-Pathogen Interactions - physiology; Human Genetics; Humans; Infectious diseases; Medical research; Medicine, Experimental; Models, Biological; Pathogens; Review Article; Systems Analysis; Systems biology; Systems Biology - methods; Translation; Virulence (Microbiology); United States
• ISSN: 1471-0056; 1471-0064; 1471-0064
• DOI: 10.1038/s41576-020-0212-5

Ongoing social, political and ecological changes in the 21st century have placed more people at risk of life-threatening acute and chronic infections than ever before. The development of new diagnostic, prophylactic, therapeutic and curative strategies is critical to address this burden but is predicated on a detailed understanding of the immensely complex relationship between pathogens and their hosts. Traditional, reductionist approaches to investigate this dynamic often lack the scale and/or scope to faithfully model the dual and co-dependent nature of this relationship, limiting the success of translational efforts. With recent advances in large-scale, quantitative omics methods as well as in integrative analytical strategies, systems biology approaches for the study of infectious disease are quickly forming a new paradigm for how we understand and model host–pathogen relationships for translational applications. Here, we delineate a framework for a systems biology approach to infectious disease in three parts: discovery — the design, collection and analysis of omics data; representation — the iterative modelling, integration and visualization of complex data sets; and application — the interpretation and hypothesis-based inquiry towards translational outcomes. This Review outlines a broad, universal framework for systems biology applied to infectious disease research. From study design and omics data collection, analysis, visualization and interpretation to translational outcomes, the authors illustrate how systems biology can provide insights into host–pathogen relationships for the betterment of human health.