Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo

Recently, the biological roles of lipid peroxidation products have received a great deal of attention not only for elucidating pathological mechanisms but also for practical clinical applications as biomarkers. In the last 50 years, lipid peroxidation has been the subject of extensive studies from t...

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Published inJournal of Clinical Biochemistry and Nutrition Vol. 52; no. 1; pp. 9 - 16
Main Authors Yoshida, Yasukazu, Umeno, Aya, Shichiri, Mototada
Format Journal Article
LanguageEnglish
Published Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.01.2013
the Society for Free Radical Research Japan
Subjects
HODE
Lipid peroxidation
oxidative stress
oxycholesterol
Review
Lipid peroxidation
HODE
oxycholesterol
oxidative stress
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Summary:Recently, the biological roles of lipid peroxidation products have received a great deal of attention not only for elucidating pathological mechanisms but also for practical clinical applications as biomarkers. In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipid hydroperoxides are formed as major primary products, but they are substrates for various enzymes and they also undergo various secondary reactions. During this decade, hydroxyoctadecadienoic acid from linoleates, F2-isoprostanes from arachidonates, and neuroprostanes from docosahexanoates have been proposed as biomarkers for evaluating oxidative stress in vivo and its related diseases. The implications of lipid peroxidation products in vivo will be briefly reviewed and their practical applications will be discussed.
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He received ”SFRR Japan Award of Scientific Excellent” in 2012 in recognition of his outstanding work.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.12-112